Analyses on specific metabolizer phenotypes showed a trend for higher frequency of CYP2D6 ultrarapid metabolizers (UMs) in remitters compared with non-remitters in patients with TRD (χ 2 = 4.76, p = 0.045), but not in patients without TRD (χ 2 = 0.02, p = 1.00, Supplementary Table S9 ).
Hierarchical multivariable logistic regression analysis accounting for regional differences revealed that the presence of chronic kidney disease was associated with higher rates of statin non-prescription (OR 1.87, 95% confidence interval, 1.69–2.08, p value <0.001), and higher age (per 1-year increase) showed a trend for prescription of low-intensity statin (OR 1.00, 95% confidence interval, 1.00–1.01, p value = 0.045) within the subset of PCI patients (N = 4,853) enrolled after the year 2011.
In contrast, patients with a dilated left atrium (LAVi ≥ 40 mL/m 2 ) showed a trend toward worse outcomes with propafenone, including higher 1-month mortality (HR 3.6, p = 0.045) and slower cardioversion (median 18 h vs. 6.4 h with amiodarone, p = 0.05) ( 56 ).
Notably, COL9A2 , a chondrogenic cough-associated gene, showed a trend toward downregulation across both comparisons (log 2 FC = −0.65, P = 0.0456; log 2 FC = −0.69, P = 0.0175), suggesting a potential role in structural changes to the extracellular matrix contributing to chronic cough through altered airway mechanics or fibrosis.
Patients treated with cangrelor showed a trend toward higher odds of achieving a discharge with a mRS 0 to 2 (40% versus 26.7%; OR, 2.42 [95% CI, 1–5.78]; P =0.046).
GSTA1 variant (12.8% of patients) showed a trend ( p = 0.046, LME) for an association with decreased clinical efficacy; however, no significant effect on azathioprine pharmacokinetics could be detected.
Upper limb tremor severity showed a trend toward higher action tremor in ET-ns ( p = 0.046, rank-biserial correlation = 0.428), but this difference did not survive correction for multiple comparisons ( p_adj (FDR) = 0.098).
The analyses between teloscore and OS of MM patients showed a trend between having longer gdTL and better MM survival, considering the quintile as a continuous variable for unweighted (HR = 0.93; 95%CI 0.85–0.99; P = 0.046) or weighted (HR = 0.93; 95% CI 0.86–0.99; P = 0.049) score, adjusted by DS staging system.
Conversely, at a dosage of 21 (range, 20–22) mg/kg/day, the posaconazole concentration showed a trend toward significantly lower concentrations compared to the dosage of 18 (range, 17–19) mg/kg/day (P=0.046, Table 2 ).
Males also showed a trend of group differences ( F (2,21) = 3.46, P = 0.046), which was due to significant difference between DLB and PDD only ( P = 0.014).
Attachment avoidance (AVD) did not significantly modulate theta during Reappraise (ps ≥ 0.19), but showed a trend toward increased theta during Suppress in the mPFC bilaterally (L mPFC: β = 0.139, SE = 0.069, t = 2.00, p = 0.046; R mPFC: β = 0.140, SE = 0.069, t = 2.01, p = 0.045).
(1989) [ 11 ] state that the incidence of serious bacterial infections showed a trend to be associated with an IgG level < 6.4 g/L (p = 0.046).
2 . Discussion In our study, the high-dose group (0.5–0.9 μg/kg/h) showed a trend of relatively weaker neuroprotective effect compared to the low-dose group (0.1–0.5 μg/kg/h) on postoperative Day 2 ( p = 0.046).
SASH1 expression showed a trend toward association with prognosis ( P = 0.0463), with the low-expression group exhibiting lower survival probability, suggesting SASH1 as a potential favorable prognostic marker, though further validation is needed.
Of note, when analyzed separately, the six cases with concomitant mutations of SF3B1 and NOTCH1 showed a trend for a progressive expansion of the CD20 dim fraction (median 19.3; P =0.0466 vs.
Similarly, education level showed a trend: those with primary or no formal education had increased odds of traditional provider use, with an odds ratio of 2.11 (95% CI: 1.01-4.43), p = 0.047, indicating statistical significance.
Yet, IH patients had higher BMI (U = 4899.5, p < 0.001), they showed a trend towards more depression (U = 459.0, p = 0.047) and had more anxiety symptoms (U = 3332.0, p < 0.001) compared to healthy controls. 27 (36%) IH patients in our sample were overweight (25 ≤ BMI < 30), 11 (15%) were clinically obese (BMI > 30), 6 had clinical depression (suggested cut-off at 23 on the BDI-II) 36 and 10 had clinical anxiety (suggested cut-off at 16 on the BAI) 31 .
In this analysis the LIBERTY and SCIENCE groups showed a trend towards reduced Anti-mask Belief that did not survive multiple comparisons correction (LIBERTY: t(587) = − 2.475, p = 0.047, SCIENCE: t(587) = − 2.537, p = 0.04).
Additionally, despite BMS patients with clinically significant OC symptoms showed a trend toward worse outcomes in sleep quality, as indicated by higher PSQI scores (median 9 [7.5–10] vs. 8 [ 6 – 10 ], p = 0.047) compared with BMS patients without clinically relevant OC symptoms; this difference was not statistically significant.
Also, those with right side SSD showed a trend towards a worse quiet/adverse ratio when compared to those with left side SSD ( p = .047), possibly suggesting that those with right side SSD are more affected by background noise.
Furthermore, glutamic acid (Glu, p = 0.059), glucose 1/6-phosphate (G1P/G6P, p < 0.100), and citric acid ( p = 0.091) showed a trend of higher levels in the DYS group than in the None group, while succinic acid was at a lower level ( p = 0.047) ( Table 3 ).
The C allele of rs10168266 also showed a trend towards increased frequency in ANA-positive patients (P = 0.047), although the lower limit of the 95% CI for the OR (0.999–4.019) was close to 1, which hindered achieving strict statistical significance.
47.8%, p = 0.005) and showed a trend towards lower valproic acid use (21.7% vs. 29.6%, p = 0.047), but more likely to receive antidepressants (53.8% vs. 39.5%, p < 0.001), benzodiazepines (39.9% vs. 26.6%, p < 0.001), and gabapentinoids (8.5% vs. 4.5%, p < 0.001).
Trunk flexor and extensor strength was lower in LBP patients, with a reduced trunk flexor/trunk extensor ratio (0.77±0.20 vs 0.96±0.16, P <0.001); hip flexor/extensor ratios showed a trend toward imbalance (left hip flexor/hip extensor: 0.60±0.15 vs 0.67±0.12, P =0.047).
Experimental mice showed significant plasticity between morning (M) and evening (E) sessions ( Figure 2C and D ; one-way RM ANOVA, F (1.333,12) = 25.53, p = .0001; post hoc ABCD (M)—ABCD (E): p = .0010; ABCD (M)—DCBA (E): p = .0013; ABCD (E)—DCBA (E): p = .0105), while control mice showed a trend towards slightly increased VEP magnitude ( Figure 2C and D ; one-way RM ANOVA, F (1.936,17.42) = 3.690, p = .0473, post hoc ABCD (M1)—ABCD (M2): p = .0611; ABCD (M)—DCBA (E): p = .1161; ABCD (E)—DCBA (E): p = .9622).