In patients with high symptom burden, the ESSPRI total score showed a trend towards improvement with iscalimab 600 mg at week 24 with dryness (LS mean treatment difference –1.0 (95% CI –1.8 to –0.2); p=0·016) and fatigue (LS mean treatment difference –0.8 (–1.7 to 0.1); p=0·067) being the main drivers of improvement.
Alterations in these two genes showed a trend towards mutual exclusivity ( P = 0.016) ( Fig. 4 , Supplementary Fig. 6 and Supplementary Table 1 ).
Again the combination of T and A alleles showed a trend of association [Fisher's p value = 0.016, Monte Carlo p value = 0.017, odds ratio, 2.62; 95 % CI, 1.17–5.90] (Table 3 ).
For AD patients, the analyses showed a trend towards reduced XA in serum of AD patients compared to control ( Z = −2.41, p = 0.016) (Fig. 2 a).
EOI2 MRD negativity was associated with superior EFS (n = 413; 47.6% MRD negativity v n = 43; 16.3% MRD positivity; P < .0001) and OS (n = 413; 66.0% v n = 43; 27.9%; P < .0001), and showed a trend toward lower CIR (n = 392; 46.1% v n = 26; 65.4%; P = .016).
Fixation: Figure 3C shows that ASD children showed a trend for worse fixation (repeated measures ANOVA on percent of trials fixated: [F(1, 48) = 6.289; p = .016; ŋ p 2 = .116]).
Knockdown of AAEL009965, an uncharacterized protein, and FASN showed a trend toward reduced CHIKV infection (Figure 6B,D ; * p = 0.0163 and 0.0820, respectively), aligning with our RNA‐seq results.
Interestingly, some alpha diversity parameters showed a trend of difference, and ADONIS analysis based on unweighted unifrac distances suggested significant differences between the two groups (results not specified, p = 0.0167).
Both tri- and bi-functional CD4 + Th1 cells showed a trend towards negative correlations with viremia, which reached statistical significance for IL-2 + TNF-α + CD4 + (Spearman r = − 0.4, p = 0.017) (Supplementary Fig. 2 A).
In the cumulative meta-analysis, the pooled OR achieved significance starting in 2009 ( P = 0.048) and showed a trend of association as published data accumulated ( P = 0.017, Figure 7 ).
Interestingly, among infertility patients, the FSHR -29 A-allele showed a trend for association with higher total testes volume (oligozoospermia based on WHO 1999, nominal P = 0.017, Table 2 ; WHO 2010, P = 0.043, Table S3 ).
None of the three CAPs showed any significant difference in either of the two temporal properties when corrected for 3 comparisons using FDR, however, the DMLN CAP showed a trend towards reduced median duration in the HET group in comparison with WT ( p = 0.017, 2-sample T-test, uncorrected).
Following Bonferroni correction for the cognitive performance family (adjusted α = 0.001), the T-SAFT90 (adjusted p = 0.005) and combined protocols (adjusted p = 0.005) remained statistically significant, while the Stroop condition showed a trend that did not survive correction (adjusted p = 0.017).
9 Elderly patients with major depression have a poorer prognosis, are less responsive to treatment, and show greater functional decline compared with younger patients, highlighting the need for effective treatment; in this phase 3 double-blind study, esketamine nasal spray combined with a new oral antidepressant showed a trend toward improved efficacy in patients aged 65–74 years (p = 0.017) but not in those aged ≥75 years (p = 0.930), with continued improvement observed in the long-term open-label study. 2 Patients with treatment-resistant depression (TRD) have higher relapse rates and decreased daily functioning, and i
After controlling for the mean pure-tone threshold at speech-relevant frequencies, activity in the left POp and preCG/postCG showed a trend of correlation with accuracy in older adults (partial r =0.604 and 0.612, uncorrected P =0.017 and 0.015, respectively, FDR-corrected P >0.05).
During lockdown, only a history of depression showed a trend towards worse adherence ( p = 0.017).
One region (MNI coordinates: 46, 28, 46) located at the middle frontal gyrus (BA8) showed a trend for differentiating coherence during the cooperation vs. dialog contrast (cooperation > dialog, t = 3.02, P = 0.017, uncorrected; Figure 7A ).
block 3 [ df (1, 37) , p = 0.003], and showed a trend between the second and third blocks [ df (1, 37) , p = 0.017].
Overall, our pooled outcomes on postprocedure symptomatic gastroesophageal reflux showed a trend toward significant reduction in favor of LHM compared to POEM group (OR = 1.81, 95% CI: 1.11–2.95, P = 0.017).
The PCS score showed a trend towards improvement at 1 postoperative month, which was then significant at 3 and 6 postoperative months, with + 5.9 points (+ 12.6%; P = 0.017) and + 9.3 points (+ 21.7%; P = 0.002), respectively.
Exteroception Regarding far accommodation, the analyses showed a trend toward a difference in position between the two groups 1 month after the end of the patrol (recovery) (U = 6; p = 0.017).
Patients showed a trend to improve at measurement D, compared to C (z = −2.38, p =.017).
HLA-B*15 also showed a trend towards protection against carriage (carriers: 5.88%; non-carriers: 25%) ( p = 0.0179).
3B (i)], assessment of 4AD levels focusing on post-AI treatment showed a trend toward increased 4AD in patients who recurred when compared with patients who responded to AI therapy [ Fig. 3B (ii), t test P = 0.018, P adj . = 0.11].
CA4 showed a trend towards right hemispheric asymmetry ( r RH = 0.490, r LH = 0.312, difference = 0.178, Z = 2.36, p = 0.018, FDR‐ p = 0.055).