Whereas the younger participants showed a trend for greater WMC for the Action group compared to the No Games group (p < 0.007), for older participants there was significantly greater WMC for the Puzzle group, but not the Action or Strategy groups, compared to the No Games group. 3.3 Component game types Assigning participants to groups based on the game types that featured in their list of games resulted in participant numbers shown in Table 3 .
In our study, individuals aged 40-50 years had significantly higher odds of having good knowledge (AOR: 11.59, 95% CI: 1.560 – 86.063, p = 0.017), and those aged above 50 years showed a trend toward better knowledge (AOR: 16.44, 95% CI: 2.150 – 125.65, p = 0.007).
Shammas Cooke showed a trend toward lower MAE in LenStar (p = 0.007), whereas the Haigis-L performance was comparable between devices (p = 0.715) ( Figure 1 ).
Under a strict Bonferroni correction criteria (α = 0.005), analysis of the combined dataset showed a trend for positive association for WNT3 (rs9890413) in individuals with deep caries and AP, both under allelic and dominant genotype models (P = 0.007).
In Kaplan–Meier survival analyses, high CAPN3 expression showed a trend toward better OS (log-rank P = 0.007).
The SNP rs3779381 was a proxy for the SNP rs3801387 on the WNT16 gene in the GEFOS dataset and showed a trend towards an association with the FN and LS BMD ( P = 0.007 and 0.005, resp.), which was above the multiple test significance threshold that was estimated at 0.001 (0.05/43).
In contrast, regional differences within the AD group showed a trend toward variability, with a significant increase in amyloid β levels in the 10N compared to AmbC (mean difference = 162, p = 0.007).
Patients with MAPT mutations showed a trend towards more severe atrophy in left entorhinal cortex (U = 2.0, z = −2.68, p = .007) and fusiform gyrus (U = 1.5, z = −2.72, p = .006) and right perirhinal cortex (U = 1.5, z = −2.67, p = .007) than patients with mutations in the GRN and C9orf72 gene and in right fusiform gyrus compared to bvFTD patients with no gene mutation (U = 13.0, z = −2.80, p = .005). 4 Discussion In this large cohort of bvFTD patients naming problems were a prominent feature of many, although not all, patients (around 50%).
The mitochondrial haplogroup J, defined by the C295T, T489C, A10398G, A12612G, G13708A and C16069T mutations, showed a trend to higher risk of kidney replacement therapy (OR: 1.957; CI 95% : 1.188–3.178; P = 0.00727), lower eGFR (BETA: -0.115; CI 95% : -0.211-(-0.019); P = 0.0186) and higher SCr levels (BETA: 0.098; CI 95% : 0.015–0.181; P = 0.0201) although not significant after multiple comparisons correction.
TKM-011-treated mice also showed a trend toward decreased CD5 + CD19 + B cells in the liver and spleen (0.8471 ± 0.5212 vs. 1.853 ± 0.8007 × 10 4 /g liver, p = 0.0074; 1.204 ± 0.6144 vs. 2.102 ± 0.8967 × 10 7 /g spleen, p = 0.0431), although this did not achieve statistical significance for CD5 − CD19 + B cells (1.509 ± 0.9114 vs. 3.286 ± 2.396 × 10 5 /g liver, p = 0.0553: 1.354 ± 1.001 vs. 2.057 ± 1.188 × 10 8 /g spleen, p = 0.0878).
Expression of the gene LNPEP (which encodes cysteinyl aminopeptidase, a protein that binds a 6 amino acid carboxy terminal fragment of Ang II and has an alternative nomenclature as the angiotensin IV (AT 4 ) receptor was significantly increased ( p =0.000039) in mononuclear blood cells from MS patients and showed a trend towards increased expression with narcolepsy ( p =0.00743).
Consistent with our results from the FLIC assay, SIFaR mutants showed a trend towards elevated food intake (Brown‐Forsythe ANOVA revealed a significant main effect of genotype on food consumption ( F 4,49.59 = 3.907, p = 0.0078), although individual pairwise comparisons did not maintain significance after multiple test correction; Figure 5D ).
Additionally, the MRI model predicted a 5-year PFS AUC of 0.673, which surpassed the individual prognostic factor ADC (ADC: 0.609) and showed a trend compared to Kep (AUC: 0.587) (P = 0.0078 for ADC and P = 0.068 for Kep).
A history of nodular disease showed a trend toward elevated PD risk (OR = 1.94, 95%CI: 1.19-3.15, p = 0.008).
After Bonferroni‐correction, the two measures did not correlate significantly in Experiment 3, r = .477; p = .0528, and showed a trend in Experiment 4, r = .603; p = .0080.
Though interaction between rs3837091, rs17997332, rs740603 showed a trend to be significant ( P = 0.008), the CVC value was insignificant (Table S6).
The Kaplan–Meier curves showed a trend that patients with a single um-EGFRm had longer PFS than patients with multiple um-EGFRms ( Figure 5A ), the difference was statistically significant(p=0.008).
Intraoperative blood loss also showed a trend of Group C (66 ± 39 mL) > Group B (55 ± 35 mL) > Group A (44 ± 32 mL) ( P = 0.008).
In particular, TIM-3 expression showed a trend of decrease at T2 significant with respect to HD ( p = 0.008) ( Figure 6 (D)).
Adaptive cognitive emotion regulation strategies (CERQ_ad) showed a trend ( p = 0.008) but did not meet the corrected threshold.
The analysis over time showed a trend over time (OR: 1.13 (95% CI: [1.03‒1.24]), p = 0.008) and substantial differences between the journals ( S3 File , section 6.1.6 ).
But we found that whereas girls showed a trend of decreasing N3 duration with age ( r (30) = -.48, p = .008, 95 % CI [-.71, −.14]), boys did not ( r (25) = .11, p = .59, 95 % CI [-.30,.49]; see Figs. 2 A and 2 B), with a statistically significant difference between correlations ( z = -2.21, p = .014, 95 % CI of the mean difference [-1.03, −.06]).
For short-term outcomes (3-month mortality, n = 7), deceased patients showed a trend toward prolonged TTPr compared with survivors (59 s vs. 27 s, p = 0.008); multivariable analysis was not performed due to limited events.
Age was associated with declines in recognition scores [ r = −0.36, t (193) = −5.36, p < 0.0001], and older participants showed a trend toward reduced learning rates [ r = −0.19, t (193) = 3.90, p < 0.008].
Among the T cells, CD4 + (42% vs 50%, p = 0.0237) and CD8 + (25% vs 30%, p = 0.09) T cells showed a trend towards increase, while double negative (CD4-CD8-) T cells (35% vs 22%, p = 0.0082) were significantly reduced in the treatment group (Fig. 6f ). 6TdG treatment resulted in significantly reduced expression of checkpoint receptors, PD-1 and Tim3, on CD8 + T cells (PD-1: 8.2% vs 3.5%, p = 0.0097; Tim3: 6.7% vs 3.2%, p = 0.0097) (Fig. 6f ).