When an association between the frequency of LOH at individual genes and tumour grade (tumour differentiation) was examined using the Mantel-extension χ 2 test for trends, BRCA1 and TP53 showed a trend to a significant increase in LOH frequency in more poorly differentiated tumours ( P =0.003, P =0.009, respectively).
Also, the change in CR group f between intra‐TX week 3 and pre‐TX (Δf 3wk‐0wk ) showed a trend when compared with the non‐CR group ( P > 0.003).
HOX B13 showed a trend of statistical association with sex and age, and a strong direct statistical association with lymph nodes metastasis (p value = 0.003).
Regarding therapy modalities, PPV led to significantly improved visual outcomes (χ 2 = 87.15, P < 0.0001), and the pre-therapy VA displayed an important role in improving vision, especially the patient’s VA ≦logMAR 2.3 showed a trend of statistically significant improvement (χ 2 = 9.00, P = 0.003).
Univariate analysis revealed that female gender, young age, and no smoking history showed a trend to association with better OS, and good performance status (21.6 months vs. 16.9 months, p=0.003), less advanced stage (19.1 months vs. 13.2 months, p=0.041), and receiving second-line treatment (20.5 months vs. 15.1 months, p=0.049) were significantly associated with better OS.
Heart rate showed a trend towards a difference between groups and an interaction with time (Repeated measures ANOVA, Effect of Time: F 1,56 = 9.46, η 2 = 0.0082, p = 0.0032; Effect of Group: F 1,56 = 3.60, η 2 = 0.57 p = 0.063; Interaction F 1,56 = 3.45, η 2 = 0.003, p = 0.069).
Interestingly, we found that high MLKL expression was significantly associated with increased DFS (median 40 months versus 25 months, P =0.0282) and showed a trend towards longer OS (median 43 months versus 28 months, P =0.0032) ( Figure 2A and B ).
Overall, the mutations did not cause increased levels of phosphorylated NF‐kB, instead, most mutations showed a trend or significant reduction in phosphorylated NF‐kB (one‐way ANOVA F [5,49] = 4.11, p = 0.0034; MAP3K7 WT vs.
Patients with high TMB (>12 reported mutations), however, showed a trend towards improved survival when treated with ICB (HR = 0.586, 95% CI [0.275–1.246]) ( Figure 3C and 3D ) ( p = 0.0035 Log-rank (Mantel-Cox) test, p = 0.211 Log rank test for trend).
Neither biochemical nor histological data seemed to predict molecularly confirmed MD, although the presence of both COX-negative and SDH-positive ragged red fibers showed a trend in this direction ( p = 0.0038).
The ACTH level in blood ( Figure 2 b) also showed a trend to increase (F(1,30) = 9.62, p = 0.004), though the increase was significant in MCAO-LM only (MCAO-KM vs.
As expected, the follow-up demonstrated that in-hospital AKI patients showed a trend to higher new onset of dialysis (2.4% vs 0.2%, p = 0.004) and lower long-term survival (89.5% vs 94.2%, p = 0.012) compared with non-AKI patients in this study.
The same Fp2-anode/F3-cathode configuration also showed a trend toward improvement (g= 0.72, p= .004).
Over time, the young age group showed a trend towards better global health, in contrast to the oldest group, which showed a trend towards worse global health ( P =0.004).
On multivariate logistic regression analysis, although thrombocytopenia [odds ratio (OR) = 1.0, 95%CI: 1.0-1.0, P = 0.06], and admission lactate (OR = 1.82, 95%CI: 0.95-3.5, P = 0.07) showed a trend towards association with mortality, only shock during hospital stay (OR = 726, 95%CI: 8-65088, P = 0.004) was independently associated with mortality.
Pairwise comparisons ( Table 4 ) showed a trend for a decreased MV at 3 months ( p = 0.004), followed by a significant MV reduction at 6 months ( p < 0.0001) and 1 year ( p = 0.002) post-treatment in the BoNT-A-naive group.
Only the left hippocampus showed a trend towards volumetric reduction (p = 0.004, uncorrected) in those patients.
In particular, the gintonin (GT 100)-treated group showed a trend similar to that of the ranitidine-treated group ( p = 0.004, Cohen’s d = 2.1 and p = 0.024, Cohen’s d = 1.5, respectively), in which the blood vessels were close to those of the normal group.
Average eccentricity showed a trend toward a higher value with increasing age (r 2 = 0.48, p = 0.004), and was higher in the older group, signifying that cells had a more elongated shape as they aged ( Table 9 , p = 0.01; Figure 8D ).
In addition, pairwise comparisons showed a trend toward lower KIF3A transcript levels (fold change = − 1.45; p = 0.004) in the femoral head of ONFH patients compared to the intertrochanteric region.
The HCMV-specific T cells detected by ELISPOT-iCL and pp65 pool showed a trend towards higher levels in Controllers than Non-Controllers ( p = 0.004 and p = 0.001, respectively; Figure 5 G,H).
At univariate analysis, only relative increase in MMP9/TIMP2 ratio proved significantly associated with sICH, while MMP9/TIMP1 ratio showed a trend toward significance ( p = 0.004, p = 0.018, respectively).
Assessment of the duration of the recruitment period showed a trend for longer durations in elamipretide treated cells, with 0.01 μM elamipretide yielding significantly longer times relative to vehicle treated cells (Fig. 2 D; P = 0.004) by an average of 9.6 min.
It was observed that radiotherapy arm showed a trend toward enhanced cytoreduction that was significant at 6 weeks post-treatment ( p = 0.004).
Also, rapid cycling cases compared to non-RC-BP showed a trend (P = 0.0041) and dominant model association (OR = 1.80, P = 0.0098) ( Table 2 ).