Interestingly, patients carrying the UGT1A9 -275A variant allele had lower AUC 0–12h /MPA-D (0.053 [IQR 0.040–0.100] ug*hr/ml/mg/m2) than patients carrying only the UGT1A9 -275T ancestral allele genotype (0.117 [IQR 0.058–0.150]ug*hr/ml/mg/m2) with a difference of marginal significance ( p = 0.05) ( Figure 4 ).
This was however of marginal significance (Fisher’s exact: P = 0.05).
For CTC removal, the difference before and after REDS was of marginal significance, with cumulative incidence greater in pre-REDS time ( p = 0.05; Table 3 ).
In females a smaller reduction of 12% was of marginal significance (p>0.05; Figures 3A and B ).
Moreover, IGD-S, IGD-PC, and IGD-P12M status were all positively and significantly associated with the 4 types of perceived negative impacts (AOR ranged from 1.69 to 3.23) except for one association (that between IGD-P12M status and labeling effect) of marginal significance (AOR 1.50, 95% CI 1.00-2.26; P =.05; see Table 4 ).
Axial length was found to be of marginal significance (p = 0.05).
After correction for multiple comparisons, a difference of marginal significance was found between underweight and overweight patients (adjusted p = 0.050).
Post-hoc analysis demonstrated that the change from baseline to year 1 was of marginal significance (0.01< p <0.05).
Finally, to assess whether genes identified by our scCRISPRi screens were enriched in T cell-related networks, we relaxed our calling threshold to include variant CRE:gene interactions of marginal significance ( P < 0.05).
The level of marginal significance of p<0.05 was used in statistical analyses to reject the null hypothesis.
However, this was of marginal significance (p < 0.05 uncorrected).
Further F contrasts confirmed a significant facilitation for the contralateral TMS compared with no TMS at both time windows (both P < 0.01) and a small trend of marginal significance ( P = 0.05) for facilitation with ipsilateral TMS compared with no TMS in the 150-ms time window.
Furthermore, the IVW method suggested a potential negative association of marginal significance between GLCA and obesity (odds ratio = 0.94; 95% CI: 0.88, 1.00; P = .05) (Fig. 1 ; Table S3, Supplemental Digital Content, http://links.lww.com/MD/M912 ), and same association direction was observed using the MR-Egger and weighted median methods (Table S3, Supplemental Digital Content, http://links.lww.com/MD/M912 and Table S4, Supplemental Digital Content, http://links.lww.com/MD/M913 ).
A decline of marginal significance was noted across all studies (p=0.05).
The difference in postoperative complications, including anastomotic leak and abscess, was of marginal significance between the 2 groups (18·8% vs. 25·7%; P =0·05).
The difference in these two models indicates that the non- additive effect was of marginal significance [F(1,208) = 0.71, P > 0.05].
After stratification by participants, the association was significant in studies focusing only on stroke patients (7 studies, OR 2.4, 95% CI 1.7 to 3.5, p < 0.001, I(2) = 10%), and of marginal significance in broader populations (7 studies, OR 1.6, 95% CI 1.0 to 2.7, p = 0.05, I(2) = 87%).
The Karnofsky performance status (p = 0.001) and the presence of tumor necrosis on pretreatment MRI (p = 0.001) were the most important prognostic factors in the multivariate analysis with the RPA-class and WBI as additional prognostic factors of marginal significance (p = 0.05).
There is a tendency for a positive structural result to increase risk and a negative structural result to decrease risk; however, the difference in these groups is of marginal significance: 2/6 groups have P values > 0.05, 3/6 are significant at the P ≤ 0.05 level, and only 1/6 is significant at the P ≤ 0.01 level.
Among the panel of markers used as IHC surrogates for basal-like phenotype, expression of CK5 and nestin inversely correlated with AR expression ( P < 0.05), and a similar trend of marginal significance was also observed for CK14 ( P = 0.05).
Prior neurological insults The ipsilateral piriform cortex did not show an effect and the contralateral piriform cortex showed a decrease in volume of marginal significance (r = −0.356, p = 0.05) ( Supplementary Fig. 3a -d, Supplementary Table 3 ).
No SNP reached a Bonferroni corrected threshold of 0.00086, with only three SNPs being of marginal significance 0.01<p<0.05 ( S1 Table ).
These studies generally include only those variants in their interaction analyses that have shown some nominal probability of marginal significance (e.g. p<0.05) in previous studies.
The Tg results in our study differ from the smaller French RCT [ 11 ], where the intervention group ( n = 32) presented lower Tg than the control group, which was only just of marginal significance ( p = 0.05) and only during the second trimester.
Because the association with the C allele was of marginal significance ( P = 0.05), and because we could not adjust for known breast cancer risk factors, we cannot exclude the possibility that such confounding factors might have led to a type I error.