Assessing causal associations of bile acids with obesity indicators: A Mendelian randomization study.

Furthermore, the IVW method suggested a potential negative association of marginal significance between GLCA and obesity (odds ratio = 0.94; 95% CI: 0.88, 1.00; P = .05) (Fig. 1 ; Table S3, Supplemental Digital Content, http://links.lww.com/MD/M912 ), and same association direction was observed using the MR-Egger and weighted median methods (Table S3, Supplemental Digital Content, http://links.lww.com/MD/M912 and Table S4, Supplemental Digital Content, http://links.lww.com/MD/M913 ).

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The findings revealed a suggestive causal association between GLCA and trunk fat percentage ( P < .05) reported by IVW analysis, as well as marginally significant causative connections between GLCA and obesity ( P = .05).

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