“of borderline significance”

Secondary patient outcomes None of the secondary outcomes were significantly different between intervention and control groups, though anxiety ( p = 0.08) and depression ( p = 0.06) measured by the HADS were of borderline significance in favour of the CARE Plus group, although the effects sizes were relatively small.

Although itraconazole was also associated with SCC, the association was modest in magnitude and of borderline significance, and no association with duration of use was found.

The trend was of borderline significance for IGF-I, T1:REF, T2 OR:1.6, T3 OR: 2.2 adjusted P trend =0.057 and significant for IGFBP-3 T1:REF, T2 OR:1.2, T3 OR: 2.1 adjusted P trend =0.042.

The association of fibrinogen and cartilage volume became of borderline significance after including fat mass in the model, indicating that this association is in part mediated by fat mass [ 46 ].

However, examination of bias-modification programmes for anxiety reveals weak effects of borderline significance (observed effect sizes, 0.07–0.42). 8 In contrast, for a mindfulness programme aimed at patients with established bipolar disorder, a significant change is observed with an effect size of 0.52 on an intention-to-treat basis.

The secondary analyses of glomerular disease in EMPA-KIDNEY showed that the benefit of the primary composite outcome or any progression of kidney disease was of borderline significance.

However, the difference between the sites was revealed to be merely of borderline significance (p-value 0.052, overlapping confidence intervals).

In the present study, the difference in NF-κB expression in patients with TNBC with a large tumor size or in the later stages of TNBC were only of borderline significance.

However, this is not consistent with the absence of a difference in ΔBMI between these 2 groups in the low-stress stratum, where the difference in energy intake was of borderline significance and nearly the same as that observed in the high-stress stratum.

Several small differences in performance of the treatments were only of borderline significance as the study was underpowered.

In contrast, the divergence between species does not significantly differ between NEX and ENDEX genes in the BA46 data set, although the human–chimpanzee difference is of borderline significance ( P human–chimpanzee BA46 = 0.06; P human–rhesus BA46 = 0.63; P chimpanzee–rhesus BA46 = 0.84).

Though these associations were only found to be of borderline significance, we should not discount the importance of FGFR2 as a BC susceptibility locus in our population.

Similarly, the VEG group had a significantly lower HOMA-IR ( Table 2 ) and reduced risk for IR of borderline significance ( Table 3 ) compared to the non-VEG group after adjusting for age, menopause, waist, glucose, and triglyceride and activity with the exclusion of diabetic cases.

Percent change in total insulin dose was of borderline significance in the model ( Table 4 ).

Mixed multilevel multivariate logistic regression showed that relative to non-use, covert use was associated with higher odds of having at least 2 births [AOR (95%CI): 1.78 (1.11–2.86), 2.56 (1.43–4.57) for women with 2–4 and ≥4 births respectively]; and being Catholic versus Protestant [1.55 (0.99–2.42)], though the latter was only of borderline significance.

The association between maternal prenatal MBzP concentrations and diagnosis of not current asthma among those with a history of the asthma-like symptoms was of borderline significance in the linear model: RR 1.17 (95% CI: 0.98, 1.41) per ln-unit increase ( Figure 3 ).

This finding was of borderline significance due to stopping recruitment early but is consistent with the results of large-scale, published meta-analyses. 9 , 17 MiECC improved a visual analogue quality-of-life measure.

The presence of rainy days was of borderline significance (OR = 0.57, 95% CI 0.31–1.07).

The lower rate of ischaemic heart disease in vegetarians was of borderline significance when adjusted for all potential mediators simultaneously (0.90, 0.81 to 1.00; supplementary table 4).

The inverse associations between maternal intake of total dairy products, yogurt, and calcium during pregnancy and the risk of childhood dental caries were of borderline significance: the adjusted ORs for the highest tertile of total dairy products, yogurt, and calcium were 0.51 (95 % CI: 0.23-1.09, P for trend = 0.07), 0.51 (95 % CI: 0.23-1.10, P for trend = 0.07), and 0.50 (95 % CI: 0.23-1.07, P for trend = 0.08), respectively.

Some previous studies have also shown that the association between APOE polymorphism and lipid levels was modified by sex ( 24 ), but in our study, the associations between the APOE allele types and lipid levels were not modified by sex, with the exception of an association of borderline significance (0.093) for triglyceride levels.

The reduction in the rate of AKI was translated into a trend (of borderline significance) toward better 30-day clinical outcome.

In conjuction herewith the expression of α-SMA and KIM-1 as markers of pre-fibrosis and tubular damage were also reduced, albeit of borderline significance.

The association was present on either sodium intake, albeit of borderline significance during low sodium.

However, when accounting for death as a competing risk, an association of borderline significance emerged, implying that the competing risk of mortality in this older, higher-risk population may have masked the association with incident KOA.