Barely Significant
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“of borderline significance”

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In the literature

Immunomodulatory molecule loci-smoking interaction Interaction of IL1B (rs1143627) and former smoking on UC risk was of borderline significance ( P interaction =.05). 39 The increased UC risk for former smoking was only seen in those with CT/CC genotype compared with never smokers with TT genotype. 39 No interaction was seen for CD. 39 In addition, 4 polymorphisms in IL10 (rs1800872, rs1800871, 1800896, and rs3024505) did not demonstrate s
These potential explana- tions for our observation with regard to breakfast are speculative; this issue requires further investigations. Although the increasing trend in risk with quantity of tea consumed is of borderline significance only, the risks are substan- tial (over 3-fold at the highest level of consumption), and there is an almost 3-fold greater risk in those who drink beverages `very or burning' hot compared to warm.
Relaxing criteria to include common variants the strongest association was provided by the SNP rs7188880 (hg19 chr16:g.74664810.A>T, risk allele A, MAF =0.46, OR =1.41, P =2.15×10 −6 ), a synonymous SNP mapping to the gene encoding RFWD3 , which was of borderline significance. rs7188880 is in strong linkage disequilibrium with the missense variant rs7193541 ( r 2 =0.65, D’ =0.96) previously shown by GWAS to influence MM risk [ 6 ].
26 – 28 We observed a slightly higher azithromycin resistance prevalence in E coli isolates from children randomly assigned to the azithromycin group at 3 months but this difference of borderline significance was no longer present at 6 months, consistent with transient increases observed in some mass drug administration trials. 4 – 7 , 29 Our study had high retention (>99%), a well characterised study population, complete adherence to the first dose of study medication, and high adherence to the full 5-day course reported by caregivers.