“nominally significant”

For associations with infections, we visualized the results of all allelic associations which had at least nominally significant p-values (P ≤ 0.05) with at least one infection category or with the “any infection” phenotype.

Here, we restricted the GRSs to index variants from the previous study 21 that were not only GWAS significant for at least one trait, but also nominally significant ( p -value < 0.05) for the remaining traits.

Proteins significantly associated with hippocampal volume and WMHs Using partial Spearman correlation, we found nominally significant associations ( P < .05) between 377 proteins and hippocampal volume in all individuals.

The resulting p -values were considered nominally significant at p < 0.05.

The rs1046322 and rs9457 polymorphisms showed nominally significant ( p < 0.05) association in all three (type 1, type 2 and combined) analyses, which remained significant in all cases after FDR correction for multiple testing.

Overall, 35 of the 87 (40.2%) meta-analyses reported nominally significant pooled results ( p < 0.05).

Finally, to characterize the functional relevance of genes driving the association between effects of LPS on MR imaging measures and expression of cell-type specific genes, we ran a Gene Ontology analysis using genes that were: (i) nominally significant p < 0.05 (MR imaging measure vs. gene expression correlation), and (ii) within the 10th decile in cell specificity for a given cell type (IT4/5 excitatory, or Parvalbumin inhibitory).

Of the 245 UKB associations (226 previously reported + 19 previously unreported associations), we find that 72% (176) show at least nominally significant ( p < 0.05 ) age-specific effects within UK women ( Figure 2 C). 37 of these 176 associations, representing 15% of all associations, have a slope with a genome-wide significant p value ( p < 5 × 10 − 8 ), constituting a more stringent criterion (strong and moderate evidence in Figure 2C).

In total, we found 227 nominally significant ( P < 0.05) differentially expressed genes (DEGs) between the treated and control groups, with 23 DEGs significant after adjustment for multiple correction ( Fig. 2c , Table S2).

Patients receiving etanercept monotherapy had less deterioration of PtGA and PtJP scores versus those assigned to methotrexate monotherapy, with a nominally significant treatment difference observed at almost all time points for PtGA and PtJP at weeks 12 and 36 ( p < 0.05; Fig. 1 ).

In the left hemisphere, nominally significant differences (uncorrected p < 0.05) were observed in three parcels: lingual gyrus ( p = 0.033), inferior temporal gyrus ( p = 0.041), and precuneus ( p = 0.048).

We repeated the analysis using both prevalent type 2 diabetes at baseline and incident type 2 diabetes during follow-up. We estimated the power that our study had to observe a nominally significant association ( p < 0.05) of each individual SNP or the genetic predisposition score with type 2 diabetes, based on the expected effect size (and its SE) of each individual SNP or the score on type 2 diabetes.

AG), and there was a nominally significant difference between the two groups with respect to log-additive model ( P < 0.05, Table 3 ).

1 Of the 208 unique genes associated with muscle strength in the meta-analysis all were significant in FHS alone (nominal P < 0.05), and 79 (38%) were also “independently” associated with muscle strength in the Illumina meta-analysis (nominally significant, P < 0.05).

A nominally significant ( P < 0.05) positive correlation was also found with PTSD, whilst the estimate with GAD was a non-significant trend ( P = 0.052).

The majority of the hypomethylated (20/28) sites showed lower M-values in the SWD group as compared with the controls; accordingly, the majority (9/10) of the hypermethylated showed higher M-values in SWD (one site, cg13823003 from GRIN2C , with a nominally significant difference at P < 0.05, analysis of variance (ANOVA) (Supplementary Table S6 ).

Eight of these 59 SNPs showed nominally significant associations with hearing difficulty in the UK Biobank (p < 0.05; S8 Table ), including both loci that reached genome-wide significance in the largest previous GWAS of ARHI[ 4 ]: rs4932196, 54 kb 3' of ISG20 (p = 2.6x10 -5 in the UK Biobank); and rs5750477, in an intron of TRIOBP (p = 1.3x10 -6 ).

Results were considered nominally significant at p < 0.05 (two-tailed).

We identified 74 nominally significant differentially methylated regions ( p < 0.05) in the mitochondrial genome, between anatomically separate cortical regions and the cerebellum in matched samples ( N = 3 matched donors).

Genetic correlation and colocalization analyses Among the 94 identified significant associations, LDSC analyses detected nominally significant ( P < 0.05) genetic correlations between seven metabolite-cancer pairs (Additional file 1 : Table S8).

Prostate cancer risk also showed nominally significant positive associations with the long TL alleles for three of the nine SNPs ( P < 0.05) ( Supplementary Material, Fig.

A 2‐sided P <0.05 was regarded as nominally significant, and a BH‐adjusted P <0.05 was considered statistically significant.

CSF and plasma levels of AMD and CSF levels of cystatin M showed nominally significant associations ( P < 0.05) with microbleeds in plasma ( Supplementary Table 6 ), in the same direction as significant associations with WMHs and WM-PVSs, respectively.

The MR‐Egger test showed a nominally significant causal effect ( P <0.05) of CHD on a lower level of mtDNA CN (β=−0.030 [95% CI, −0.055 to −0.0045]; P =0.029) (Table S7 ).

Differentially methylation CpG sites The epigenome-wide differential methylation analysis revealed 26982 CpG sites that differed between obese and lean individuals with nominally significant p-values (p ≤ 0.05).