“nominally significant”

Epigenome-wide association study of Frailty Index Testing 723,029 lsBINs in 50 FI discordant MZ twin pairs (Gr1) implementing paired t tests revealed overall N D = 27,485 bins that showed nominally significant associations ( P < 0.05), and of these, the top 20 association signals were ranged P = 7.01 −5 to 2.17 −6 .

Using a nominally significant cutoff ( p < 0.05), 30 module-trait relationships emerge, with a range from zero to six significantly correlated modules per trait.

For any medication with a nominally significant association ( p < .05), the same analysis was repeated in the chemotherapy group to test for nonspecific effects.

After filtering to the 176 clock-disease associations that were Bonferroni significant in the Cox models, there were 32 instances where the AUC improvement between the null and full model was greater than 0.01 and nominally significant at P < 0.05 (Fig. 2 and Supplementary Data 8 ).

A total of 19 HLA alleles had nominally significant maternal and/or fetal effects on BW ( P <0.05; Supplementary Table S7 , available as Supplementary data at IJE online); 13 of the 19 alleles had evidence for a maternal effect only, four alleles primarily had evidence for a fetal effect only and two alleles had evidence of both.

After additionally adjusting for diagnosis, only ERLIN2, APMAP, and COX19 retained nominally significant positive correlations with pTau231 ( p < 0.05), though none survived correction for multiple comparisons.

Raw P < 0.05 was considered nominally significant, whereas FDR-adjusted P < 0.05 was considered significant after correction for multiple comparisons.

Out of 14 shared knowns that had genome-wide significant associations in OE, 7 had nominally significant ( p < 0.05) and directionally consistent associations in MCDS.

For the five types of gastrointestinal diseases, S-LDSC results showed that each disease exhibited nominally significant heritability enrichment in multiple tissues ( P < 0.05).

We retained for downstream analyses all loci with nominally significant binomial p values ( p < 0.05) and at least 2 reads (10%) mapped to any allele.

Of these, five showed nominally significant ( p < 0.05) association with MS ( Figure 1 , Table 2 ).

The resulting p -values were considered nominally significant at p < 0.05.

The 36 nominally significant miRNAs ( p < 0.05) identified in the PDN/PDD comparison from LIMMA were used to classify disease state (See Figure 2B ), though with more limited accuracy than the PD-control model (absolute error rate = 13.8%, sensitivity = 81.2%, specificity = 88.9%).

Tier 1 findings included putative causal associations from the main analysis, which were directionally consistent, at least nominally significant in all analyses and showed no evidence of pleiotropy, that is, the Egger intercept P value >0.05, whereas tier 2 included the remainder of putative causal associations from the main analysis.

They first extracted nominally significant signals ( p <0.05) from three GWAS studies (WTCCC, German, and NIMH GAIN datasets; Fangerau et al., 2004 ; Wellcome Trust Case Control Consortium, 2007 ; Baum et al., 2008 ), and prioritized potential candidates based on independent, converging lines of evidence from various bioinformatics resources.

Fisher-Irwin exact tests of association determine the best possible mode of genetic effect at a nominally significant p-value < 0.05.

We selectively included 44 diseases (excluding cancer, which is a limitation to be noted) in the first part of phenome-wide association analysis (PheWAS) and identified nominally significant associations ( P < 0.05) between the SES-associated variants and CHD.

eQTL analysis of the remaining 26 loci (69 protein-coding genes) identified 22 SNP-gene combinations that were nominally significant ( t -test P < 0.05) in all, ER+ or ER− breast cancers (Supplementary Data 6 ), nine of which remained significant after taking account of multiple testing (FDR adjusted t -test P < 0.1,Table 3 ).

To limit multiple testing, we focused our analyses on the independent, regulatory variants with the strongest main effects on BMI, thus testing only the LD-clumped cis -regional variants of the age-DE SAT ASPC genes that showed nominally significant ( p <0.05) effects on BMI in the non-age-adjusted GWASs and landed within open chromatin regions of ASPCs[ 59 ].

The authors reported nominally significant associations (P < 0.05) for 5 CpGs using unadjusted Cox models.

Some nominally significant correlations (uncorrected p < 0.05) were also observed in AN and BN groups (details in the Online Supplementary Material, Tables S1-S3).

AG), and there was a nominally significant difference between the two groups with respect to log-additive model ( P < 0.05, Table 3 ).

Average methylation values for each cytosine within the Fr_BAG5_APOPT1 fragment by group and haplotype and nominally significant p -values ( p < 0.05) for every analysis conducted are given in Supplementary Table S5 .

Here, we restricted the GRSs to index variants from the previous study 21 that were not only GWAS significant for at least one trait, but also nominally significant ( p -value < 0.05) for the remaining traits.

In the KEGG pathway analysis 17 pathways were nominally significant but none passed the threshold of an FDR-corrected p-value < 0.05.