“nominally significant”

Meanwhile, when covariates were included, 7,350 genes were nominally significant (p < 0.05), and 5,532 genes remained significant after multiple comparison correction (padj < 0.05).

Of the remaining eight risk SNPs without significant signals, they found nine genes among four SNPs that were at least nominally significant ( P <0.05).

Evidence of 22 (51%) non‐genetic biomarkers exhibited a nominally significant effect ( p < 0.05) on AS, and 7 associations (14%) showed small‐study effects.

2 ; Supplementary Figures 1 , 2 ), and a nominally significant p-value (unadjusted p-value < 0.05) was used to define FSCV DEGs in these signatures.

Several genera, including Clostridium, Ruthenibacterium, and Dorea, showed nominally significant associations (p < 0.05).

In the Results, we present nominally significant results ( P < 0.05) results with a Bonferroni correction for the number of SNPs being analyzed ( α /2; P < 0.025), which was consistent with the approach used in a prior study assessing genetic variants and GxEs as predictors of mental health trajectories (Latendresse et al. 2011 ).

Causal estimates produced by the different methods had consistent direction of effect compared to the IVW estimate and all save MR-Egger were nominally significant (i.e. p < 0.05).

Of the 46 SNPs, 17 Bonferroni-replicated ( P <0.05/46=0.0011), and 14 additional were nominally significant ( P =0.05); there was a clear distributional enrichment for smaller P -values, e.g., 67% met nominal or better significance, far more than the 2.5% expected by chance (requiring same direction; Supplementary Figure 4 ).

pneumoniae DNA status were each associated with a reduced of FEV 1 approximately 400 mL, although neither was nominally significant at a level of P < 0.05.

We found 99.3% (5442/5478) of the FDR significant associations also had a nominally significant ( p ≤ 0.05) association in the Spearman rank test (Fig.

Nevertheless, in the Breslow–Day test, we detected that only two (rs72854462 and rs1438898 mapped to TEX41 gene) of the 821 tested SNPs were nominally significant ( p < 0.05), signaling heterogeneity in the odds ratios (OR) of these variants between Mexico and Colombia (see Supplementary Table 3 ).

Even among nominally significant DEGs (nDEGs p < 0.05; cortex n = 1567; striatum n = 906; cerebellum n = 487), there was limited overlap, with significant similarities being seen only among downregulated genes (Fig. 2 c and Supplementary Table 4), indicating that the effects of Mbd5 reduction are largely different across these three brain regions.

Only one of these SNPs showed a nominally significant association ( P < .05) in our data (rs909253, proxy for rs1041981, r 2 = 0.93; OR = 1.12; P = .005).

3.3 Univariate linear regression analysis Among the 831 features investigated, 42 showed a nominally significant difference at a p = .05 level between the n-3 LCPUFA supplementation and the placebo group.

To this end, a threshold to the cluster height was gradually reduced until a Kruskal–Wallis test of the gene-specific minimum p values from the eQTL analysis indicated nominally significant heterogeneity between the emerging sub-clusters (Kruskal–Wallis p < 0.05).

Among complete blood count, red cell distribution width, PLT, and PCT showed nominally significant pre–post differences ( P < .05).

A nominally significant result was determined at the P < 0.05 threshold.

None of these loci was even nominally significant ( p > 0.05) in the Han Chinese subgroup.

Very little epistasis was apparentin the hotspot regions, with less than 7% of trans methQTL in these hotspots possessing a nominally significant (P<0.05) epistatic interaction, and less than 1%of trans methQTLwith a significant epistatic interaction(see Supplementary Table 3 ).

3.6.1 Hub disease categorical enrichment In total, we found 14 nominally significant ( p < 0.05) disease category-hub enrichments.

Results for the well-being score were all directionally consistent but none were nominally significant ( P < 0.05). 4. 2-sample MR with non-overlapping depression GWAS Using the PA and ST instruments identified in our MRLap analysis we provide further evidence for the role of PA in depression using the summary statistics from the Wray et al.

Though 12 of the 180 SNPs showed nominally significant heterogeneity (P<0.05) none survived adjustment for multiple testing (a full list of these 180 SNPs are provided in the Table S1 ).

The nominally significant p -value was defined as 0.006 ≤ p < 0.050, indicating suggestive evidence for potential causality.

Interrogating our GWAS data set for candidate genes that have been previously proposed to be involved in pathogenesis of OM, we found 45 out of 82 genes demonstrated evidence of nominally significant association, with intragenic SNPs or nearby SNPs of P value<0.05; Supplementary Table 6 ), such as SMAD2, SMAD4, NELL1.

Six of these 13 associations were directionally consistent, but none were nominally significant (p<0.05).