“nominally significant”

For the OR, FA showed a nominally significant negative association at the uncorrected level (β = − 0.187, t (110) = −2.084, p =.039), but this did not survive FDR correction (FDR adjusted q = 0.118).

The statistical analysis revealed that there were nominally significant main effects of stress on the distance traveled in the dark chamber (Figure 2 B, left: F 2,66 = 3.40, P = .0394) and time spent in the light chamber (Figure S1 A: F 2,66 = 3.71, P = .0297).

Progression-free survival (PFS) was also significant ( p = 6.730 × 10 −3 ; q = 0.0143), disease-specific survival (DSS) was nominally significant but borderline after FDR correction ( p = 0.0399; q = 0.0532), and disease-free survival (DFS) was not significant ( p = 0.0903; q = 0.0903) ( Figure 4 , Table S3 ).

We find that the two depressive symptoms lead-SNPs have the predicted sign for subjective well-being, and one is nominally significant ( p = 0.04).

For LOX1.3, the minor allele showed a nominally significant association with clinical CHD but in the opposite direction than that seen in the ADVANCE study (HRR 0.92, P = 0.04 for the additive model).

For example, in LiAc, GxE was seen for all reporters in that BY showed no significant change in UPS activity compared with SC for any reporter, while RM showed at least nominally significant reductions for all reporters ( t -test for effect of environment per strain, P ≤ 0.04).

Four carriers of codon 60R had decreased insulinogenic index (β = −83% [−152 to −13], P = 0.02) ( Table 5 ), which remained nominally significant when analyses were adjusted for the difference in BMI (β = −72% [−140 to −5], P = 0.04). 243R was nominally associated with decreased FPG (β = −0.08 mmol/l [−0.16 to −0.01], P = 0.04) ( Table 5 ).

Phyla-level phylogenetic binning of 16S rRNA data revealed a nominally significant correlation between the Bacteroidetes:Firmicutes ratio and age- and sex- adjusted BMI (r = 0.116; p = 0.04), but no significant correlation with metabolic syndrome traits [fasting glucose (r = 0.075; p = 0.19), systolic or diastolic blood pressure (r = 0.016; p = 0.78 and (r = 0.043; p = 0.45), respectively), fasting triglycerides (r = 0.078; p = 0.17), HDL-cholesterol (r = −0.052; p = 0.36); all adjusted for age and sex) Results from unweighted UniFrac analysis [16] also did not distinguish among the subjects based on BMI ( Figure S5 ).

After Benjamini–Hochberg correction across the 23 panel-level Spearman tests, 10 of 11 nominally significant correlations were retained at q < 0.05; BNIP3 (raw p = 0.040, q ≈ 0.082) was the gene that fell below the BH threshold ( Table S1 ).

ANN NEUROL 2025;98:1027–1043 Although WMH volume showed a nominally significant association with hippocampal volume ( p = 0.04) in the P‐tau181‐based BM‐CTL group, this did not remain significant after correction for multiple comparisons.

There was a nominally significant difference in shape-evoked variability between the DYS-high and DYS-low groups ( t (18) = 1.80, p = 0.04; Fig. 5 D), but this comparison did not survive Bonferroni correction.

When stratified by age, the difference between BHI and SEER in overall cancer incidence was only nominally significant for patients age 55 (proportion test, adjusted p=0.04) ( Supplementary Figure 2 ).

The p.(Glu492Lys) variant in ATP1A2 occurs in 18 cases versus 298 controls, a result which is nominally significant at p = 0.04, but again this is not statistically significant after correction for multiple testing.

We also found a nominally significant association of rs13265422 with frequency of binge drinking in the last 30 days, a measure of alcohol abuse ( r = 0.06, t = 2.06, P = 0.040; girls: r = 0.09, t = 2.48, P = 0.013; boys: r = 0.02, t = 0.52, P = 0.60), and again there was no significant difference between boys and girls ( z = 1.33, P = 0.18).

In general, no significant heterogeneity was observed for the 24 top SNPs of the study-wide significant and suggestive associated loci, that is only one SNP (rs3403289 at 2q36.1 PAX3 ) showed nominally significant (Cochran's Q test p=0.04, Table 1 ) heterogeneity between the discovery cohorts, but was not significant after multiple testing correction.

Interestingly, rs4506565 (but not rs7901695) shows a nominally significant effect on transcript relative expression of TCF7L2 (p = 0.04) from sQTLseekeR first-phase GTEx data, although clearly this requires additional functional validation.

SNP rs2630488 within GNRHR showed a nominally significant association (p = 0.04) with estradiol levels in post-menopausal women.

Correlation of MS admissions with smoking prevalence There was a nominally significant inverse correlation with smoking but this was lost in the weighted regression ( figure 2a ; overall – r = −0.55, p = 0.04, r sw = −0.49, p = 0.08; r pw = −0.25, p = 0.39; figure 2b ; males – r = −0.52, p = 0.06, r sw = −0.47, p = 0.09; r pw = −0.21, p = 0.47; females – r = −0.56, p = 0.04; r sw = −0.49, p = 0.08; r pw = −0.25, p = 0.38).

That being said, there was a nominally significant association (OR = 1.26, p -value = 0.04) of the PRS-CRP constructed using a limited number of genome-wide significant SNPs, mimicking the one used by Huang et al. 8 , with moderate-to-severe OSA with EDS, compared with no OSA.

In exploratory subgroup analyses, ulcerative ileocolitis showed a nominally significant genetic association with perianal disease ( p = 0.04).

The GO gene set involved in telomere maintenance showed nominally significant enrichment with IEAA ( P = 0.04, Supplementary Table 11 ), which is consistent with our results surrounding the overlap between IEAA and telomere length associated genes.

We found a significant association between the genetic variation at DHX32 (rs12356233, corrected P =0.019) and a nominally significant association between RGS12 and the response to adalimumab (rs4690093, uncorrected P =0.040).

At the subcortical level, a nominally significant uncorrected effect was observed for HC versus ET in the left thalamus ( p = 0.04, uncorrected, t = −2.07), with sub-threshold trend-level uncorrected effects in HC versus LTG ( p = 0.12, uncorrected, t = −1.58) and HC versus HTG ( p = 0.06, uncorrected, t = −1.91).

Nominally significant lower SQ scores were found in the EE-dominance group compared to the balanced empathy group ( t (619) = − 2.02, p = 0.04, ƞ p 2 = 0.006).

The evidence for three populations rather than two is nominally significant as shown in the formal likelihood ratio tests ( p = 0.04; Fig. 2 c).