“nominally significant”

An in-depth analysis of the sites making up the DNAge® epigenetic clock showed that some sites and regions showed a nominally significant association with trisomy.

Genotyping When analyzing SNP genotype associations under the three inheritance models, the variants rs10771279 ( ITPR2 ) in the codominant and recessive models, rs4903064 ( DPF3 ) in the codominant, dominant, and recessive models, and rs7579899 ( EPAS1 ) in the recessive model showed nominally significant differences in genotype frequencies between RCC cases and healthy controls ( Table 2 ).

A two-tailed P value <0.05 was considered nominally significant.

We restricted this analysis to genes with Class 1 nominally significant T1 P -values in the Discovery series.

All samples except one contributed to the signal in the same direction and three samples were nominally significant.

Gene-phenotype associations with p-values < 0.05 were considered nominally significant.

For tryptophan and phenylacetylglutamine, the treatment effect was opposite to that observed for leucine, and only nominally significant.

Conversely, a nominally significant positive association was detected for the term “action”, indicating that brain areas associated with this term seem to be especially affected by volume reductions (nominal p < 0.05). 3.4.2 Spatial associations with neurotransmitter systems The spatial colocalization analyses with neurotransmitter atlases indicated a nominally significant negative association between the ALE map of the analysis “GM_loss_acute” and the distribution of serotonin transporters (5-HTT) (nominal p < 0.05; Fig. 4D , Supplementary Table 11 ).

Causal effects of Circulating lipid metabolites on SZ Nominally significant causal effects were detected for genetic signatures underlining the levels of seven circulating lipid metabolites in serum on SZ.

We observed nominally significant positive associations with two coding variants in ethnic-pooled analyses ( NCOR2 : His52Arg, OR = 1.79; 95% CI, 1.05–3.05; CALCOCO1 : Arg12His, OR = 2.29; 95% CI, 1.00–5.26).

A P value less than 0.05 was considered nominally significant evidence for a potential causal association ( 23 , 28 , 29 ).

Most of the top SNPs were not the same, although many that were nominally significant in one were also in the other.

Among all tested GO terms, seven flagellum-related terms were identified: all seven were nominally significant ( P val < 0.05), and three out of seven remained significant after multiple-testing correction ( q val < 0.25) ( Fig. 6 ).

However, some enhancer/promoter region SNPs scored only nominally significant in males and others in females (e.g., rs6499861), with p values that do not survive multiple hypotheses adjustments (necessary here because we have yet to identify the exact SNPs associated with transcription).

Most of the genes associated with these nominally significant variants, including BCL11A ( Supplementary Table S4(2) ), are, interestingly, part of the BCL11A functional/physical and co-expression network. 4.

Building on their work, future studies with larger GWAS samples for rarer personality disorders (eg., histrionic, paranoid) and replication cohorts will be essential to determine whether the nominally significant but Bonferroni‐non‐significant associations represent true effects or false negatives. 4 Beyond these methodological considerations, the present study raises important questions regarding the biological mechanisms underlying the observed bidirectional relationships between pain and mental disorders.

Functional enrichment analysis was performed on all nominally significant metabolites listed from the univariate analysis using Fisher’s exact test and p-values were adjusted by the FDR correction.

Conversely, a nonzero estimate obtained from MR analysis may still be observed, even if the associations of SNPs with the outcome are only nominally significant. 39 2.8 Protein–protein interaction, druggability evaluation, and safety evaluation To explore the potential interactions between the identified proteins, we constructed a comprehensive protein–protein interaction network using the STRING database ( https://string‐db.org/ ).

In typically developing children, the association between attention problems and SSRT ( F (1,29) = 4.43, p = 0.044) was nominally significant, but this did not survive FDR correction for multiple comparisons.

In general, genetic correlation estimates are characterized by high uncertainty, although the strong positive estimates between WTM F and SLM F , and WTM M and SLM M are nominally significant based on | r G | > 1.96*SE.

Due to the exploratory nature of this analysis, we chose to further analyze all nominally significant DMRs which also pass the post-hoc methylation difference filtering. 1,316 DMRs were identified with a diet-associated methylation change in at least one strain ( Fig 5A and S16 – S18 Tables).

Although a small number of nominally significant results were produced, no gene-set enrichment survived correction for multiple testing ( Supplementary Table S8 ).

We identified 13 pathways with nominally significant P -value (< 0.05); however, none of the pathways remained significant after multiple testing correction (Additional file 1 : Table S8).

Pathway analysis identified 6 nominally significant pathways including the mitophagy pathway.

Results were robust to sensitivity analyses for the influence of dietary adjustment ( Table S2, Supplementary Materials ) and weight–height ratio adjustment ( Table S5, Supplementary Materials ) The nominal association of fish with higher fasting glucose in Karachi remained nominally significant in sensitivity models adjusted for fruit and vegetable consumption instead of our unhealthy diet score index, but was not significant in models unadjusted for diet; however, the point estimates for association were similar across the three models.