“nominally significant”

CCL26, a marker of eosinophilic inflammation, was the most significantly upregulated biomarker in EoE, was also elevated in BCH, and remained nominally significant even after adjusting for maximum eosinophil count.

A p value of < 0.05 was considered nominally significant and because of the high number of tests performed, all p values were corrected for multiple testing.

We found that only a few of the alcohol use–associated loci reported in Europeans ( 12 ) were nominally significant in this study (table S13).

Also, nominally significant linkage with maximum number of cigarettes smoked (MaxCigs24) was found on 16p12.3 in a linkage meta‐analysis (Han et al . 2010 ).

Future studies could investigate nominally significant associations (Additional file 1 : Table S2 and Additional file 1 : Table S3) in larger cohorts and/or meta-analyses, to determine whether any of these potential associations contribute to the pleiotropy detected in C9ORF72 expansion carriers.

Regions of the genome that were nominally significant in both populations were also identified.

A total of 617 nominally significant DE_circRNAs (115 upregulated and 502 downregulated) were found in GSC-exos ( Figure 1B ).

However, the other GWS genes were not represented by single marker GWS loci and reflected the accumulation of nominally significant associations across those genes.

While some APOE SNPs had nominally significant association with hallucinations, they did not survive Bonferroni correction.

The associations of COR with EF at baseline ( r = −0.318, p = 0.029, FDR-adjusted q = 0.139), MIF with EF at follow-up ( r = −0.356, p = 0.014, FDR-adjusted q = 0.084), and COR with EF at follow-up ( r = −0.363, p = 0.012, FDR-adjusted q = 0.084) were nominally significant before FDR correction but did not survive correction for multiple comparisons.

Overexpression was observed for 34 of the 49 genes including 19 of the 20 nominally significant genes ( Tables 4 and S7 ).

The remaining nominally significant associations—Phoenixin-14 with body mass index ( r = 0.382) and weight ( r = 0.361), Alamandine with glucose ( r = 0.308), and Cerebellin-1 with triglycerides ( r = 0.262)—did not retain significance after correction for multiple comparisons ( Table 3 ).

We retained an explanatory variable if its effect was nominally significant at the conventional 5% level.

P < 0.05 was considered nominally significant.

We found 36 and 37 nominally significant metabolites when comparing AMD-GA and AMD-Mixed to controls.

H3 CETP (β HDL-C = −0.05, p = 0.016; OR HDL-C = 1.34, p = 0.040 and β TG = −0.16, p = 0.033) and H8 CETP ( βHDL-C = −0.14 p = 0.001; OR HDL-C = 2.60, p = 0.002 and β TG = −0.33, p = 0.032; OR TG = 0.50, p = 0.026) have at least a nominally significant lipid-lowering effect on both outcomes.

47 Potential small study bias or publication bias (that is, the likelihood of small yet nominally significant studies being published selectively) was examined by visual inspection of constructed funnel plots and analytically using Egger’s test. 48 Egger’s method plots linearly the standard normal deviate (natural logarithm of relative risk/standard error (SE) of relative risk) and precision (1/SE of relative risk) as independent variables, with test results based on the P value of the regression constant.

Rates of dialysis showed a nominally significant temporal decrease among patients with preeclampsia who had AKI, while there was no significant change in dialysis rates among those with preeclampsia who did not have AKI.

It is noteworthy that three variants within GREB1 area (close to rs13394619) and CDKN2B-AS1 (close to rs1537377) also demonstrated nominally significant relationships with endometriosis [ 33 ].

Other SNP effects previously associated with imaging phenotypes were nominally significant, but did not withstand correction for the number of SNPs tested.

[ 15 ] first found nominally significant transmission disequilibrium of 332 bp in RS3 in 115 non-ethnic-matched ASD families but not by a low power in Bonferroni correction.

Notably, IL12RB2 showed significant sex-dependent differential expression in whole blood and monocytes after multiple testing correction and was nominally significant in natural killer cells.

Table 4 summarizes the associations showing nominally significant cases-only P values in our study.

Patients carrying one or two BDNF minor alleles (GA or AA genotypes) showed a nominally significant association with healthy controls, implying a protective effect of this allele for mood disorder.

From the meta-analysis between SB and AUD severity for the rare and low-frequency variant analysis, none of the nominally significant genes or pathways remained genome-wide significant after multiple comparison corrections (Table S10 ).