“nominally significant”

While HLA-DRB1*15:01 reached the significance threshold in the meta-analysis (p=8.38×10 −5 ), it was only nominally significant in the Colorado study, with a low probability of replication (PPR=0.35%) ( supplementary table S5 and figure S3 ).

Differential abundance testing did not reveal any metabolites with a statistically significant association with CBT response after correcting for multiple hypothesis testing, though 55 metabolites were nominally significant (Table S3).

P < 0.05 was considered as nominally significant and P < 0.05/6 (0.008) was considered as significant after correcting by Bonferroni measures.

Nominally significant associations were identified in ten genes after adjustment for intragenic SNPs; CYP2A6 and two CYP2A6 SNPs attained experiment-wide significance adjusted for correlated SNPs ( CYP2A6 P ACT =4.1E-7, rs4803381 P ACT =4.5E-5, rs1137115, P ACT =1.2E-3).

Re-analysis by subpopulation showed a nominally significant reduction in the primary outcome in the subpopulation of participants enrolled in the Americas, who had characteristics consistent with clinical HF and per-protocol study medication use (Table 1 ) [ 12 , 34 ].

BFF MDI 320/10 μg and 160/10 μg reduced the rate of moderate/severe COPD exacerbations versus FF MDI (rate ratios 0.67 [95% CI 0.54–0.82; p=0.0001] and 0.71 [95% CI 0.58–0.87; p=0.0010], respectively; these endpoints were not included in the Type I error control strategy, so were nominally significant) ( table 2 ).

The nominally significant variants do not appear to be in LD with G2019S or M1646T.

Nominally significant effects can be found in Supplementary Table S2 – S5 .

A recent analysis of haplotypes comprising the rs6857, rs2075650, rs769449, rs429358, and rs7412 SNPs mapped to the APOE gene cluster also suggested a nominally significant adverse effect on longevity in carriers of the ɛ3/ɛ3 genotype, that is, independently of the ɛ4 and ɛ2 alleles (Sebastiani et al., 2019 ).

Furthermore, there were only nominally significant differences between LADA and GADA-only LADA cases.

However, we found nominally significant associations in both male and female T2DM patients.

The utility of this approach is further evidenced by the fact that the 64 GWAS SNPs were enriched in nominally significant eSNPs as compared to a random selection of 64 variants from the entire set of SNPs used in eQTL analysis.

Based on the observed allele frequency of the rs8019381 SNP, the current samples yielded the power of 0.894 for detecting nominally significant results.

Among these nominally significant metabolites, leukotriene B4 was the most markedly elevated (2.8‐fold) (Figure 2C ) in the recurrent flare group; the amino acids creatine, sarcosine, and L‐canavanine were moderately elevated; and the most markedly decreased metabolites were lipids and lipid‐like molecules.

Notably, only MDD and SCZ showed nominally significant correlations with GERD, whereas BIP did not, suggesting trait-specific rather than pervasive genetic overlap.

Pathways, such as glycosylation and glycoprotein processes, achieved suggestive significance when the attack data were included and were nominally significant in the data set excluding the patient, with overall patterns and directions of change consistent.

The other two variants also showed nominally significant associations with other lobar volumes.

Analysis of individual user-device pairs showed similar results, save for a single nominally significant difference observed for one user (MJ) within one cell category (peripheral blood lymphocytes).

With the exception of white matter volume in the left hemisphere, IDP associations were not significant at the prespecified 10% FDR threshold, though they were consistent in magnitude and direction with nominally significant unadjusted p values in contralateral structures and using two ALS outcome GWAS.

A further SNP, rs671330, in chromosome 6, has a nominally significant p -value in the approximate test (ranging from 0.048 to 0.040 with increased shrinkage), but again this SNP has not previously been shown to be associated with lung cancer risk.

A nominally significant association was observed between rs984222 ( TBX15-WARS2 ) and FPG.

By contrast, the 13 proteins also nominally significant in serum revealed no significant difference between the groups after correcting for multiple testing.

In our sample, nominally significant associations were noted between C4A peripheral mRNA levels and PANSS general psychopathology as well as total symptoms severity, which corroborate prior evidence indicating a relationship between higher C4A expression levels in PBMCs and more severe psychotic symptomatology [ 21 ], albeit it should be stressed that our limited sample size could not permit definite conclusions.

p values up to 0.01 were considered statistically significant, while p values between 0.01 and 0.05 were considered nominally significant. 3.

Male‐specific variants were identified as those that (1) were significantly associated with longevity in males ( p male < 5 × 10 −8 ) but not significant in females ( p female > 0.05), and (2) exhibited a nominally significant sex difference ( p ‐value testing for difference in sex‐specific effect estimates, p difference < 0.05; formula 1 ).