“nominally significant”

This notwithstanding, several SNPs near SYT10 showed a nominally significant association with p.G2019S in IPDGC patients (Supplementary Table 3 ) while this was not the case for any of the 90 previously reported PD risk SNPs.

5 ), which indicates that the concentration of nominally significant results in this gene is not merely due to LD.

Fourteen sites were nominally significant for the distant relationships (third- to fifth-degree relatives) of which eight were significant after Bonferroni adjustment.

After removing DNMs with at least one read carrying the alternate allele in parents, the AFR/AMR and AFR/SAS differences became only nominally significant (Supplementary Fig. 5C ).

Furthermore, despite the limited statistical power of our sample size, we did observe a nominally significant association at rs138269346 COL4A1 for nonlobar ICH risk.

These findings were nominally significant and withstood sensitivity analyses, showing no substantial heterogeneity or pleiotropy.

Other nominally significant associations with the RR for the primary end point or for mortality occurred for the following: rate of crossover from experimental to control group (Figures S4 and S5 ); CABG trials; and trials allocating more invasive treatments to the experimental arm.

This study found no genome-wide statistically significant associations ( P < 5 × 10 –8 ); however, TMEM132D , LRRC7 , and STIP1 were identified as nominally significant [ 109 ].

A subsequent pathway analysis (enrichment and topological) of the significant metabolites resulted in three nominally significant enriched pathways for contact allergies and one pathway for hay fever that are displayed in Table 5 . 3.7.

Due to the large number of association tests performed, there will be many nominally significant results.

When cancer sites were more finely divided, a nominally significant excess of female breast cancer was observed (31 [3·0%] vs 17 [1·7%]; along with four vs one male breast cancers), but that difference is based on small numbers of events and was not significant after appropriate allowance was made for multiple comparisons (as prespecified).

In contrast, extending SNP inclusion to the genome-wide nominally significant variants substantially improved predictive accuracy [ 47 ].

Conditional logistic regression of the combined dataset demonstrated nominally significant association of JIA with lower methylation at CpG_9, such that a 1% increase in methylation equates to a 6% decrease in risk of being a JIA case (OR = 0.94, 95% CI: 0.87, 1.00; p = 0.064).

For region-level analyses, given the 816 MR estimates, a Bonferroni-corrected P -value was set as 0.05/816 (6.127 × 10 −5 ), and meanwhile P < .05 was regarded as nominally significant.

After covariation with total tau, we found seven nominally significant markers in plasma and one nominally significant marker in CSF.

For example, of the total 1,297 genes with a nominally significant gene-based p-value (Pgene-based ≤ 0.05) in the MA subgroup, 132 genes also produced Pgene-based≤ 0.05 in the MO subgroup.

Effect sizes were modest for these nominally significant findings.

However, P < 0.05 was assumed nominally significant of a causal association.

As such, nominally significant results should be interpreted as hypothesis generating, rather than confirmatory evidence.

It should be noted that, while all eGFR‐based secondary outcomes are consistent with the primary endpoint, eGFR‐independent secondary outcomes (e.g., albuminuria‐based ones) are only nominally significant because no adjustment of type I error inflation due to multiple testing was performed, and should therefore be considered exploratory.

This gene was nominally significant and up-regulated among the feed efficient animals in both populations of steers.

When comparing CKB and UKB estimates we found only a nominally significant difference in the relationship between BMI and life satisfaction in rural males only ( P difference = 0.04, Supplementary Table 8 ).

They identified 303 ( p < 0.05) sites with nominally significant differences between responders and non-responders, but none were significantly different after correction for multiple comparisons.

No causal estimates were statistically significant, apart from the IVW m estimator after covarying for mean cortical TH, which was nominally significant ( β IVWm = 0.025, SE IVWm = 0.012, P IVWm = 0.038; Fig. 5a, b , Tables S 9 & S 10 ).

Furthermore, we found suggestive evidence for the effect of sleep duration and morningness on T2DM risk with the modified IVW model, whereas the nominally significant effects disappeared when utilizing alternative MR models in the sensitivity analyses.