“nominally significant”

We observed 8 nominally significant associations in the replication cohort, more than would be expected under the null ( p = 0.0098 based on a binomial distribution with 5% chance of success).

Among the other loci with P < 1 × 10 −5 in the discovery set, one (rs10555080, aka rs72397229, on 19q12) showed a nominally significant association with DPN in the validation set ( P = 0.0098), resulting in a P value in the notable range ( P = 2.6 × 10 −7 ) in the two sets combined.

This cluster also showed nominally significant enrichment for the two overlapping GO terms "fatty acid metabolic process" (GO:0006631, p = 9.8x10 -3 ) and "lipid metabolic process" (GO:0006629, p = 0.029), which include Abhd5 , Apoe , C3 , Ces1d , Echdc2 , Fabp4 , Fads3 , Gpam , Hsd11b1 , Liph , Lpin2 , Lpl , Pmvk , Ptgs2 , Scd1 , Sftpb , and Vldlr .

[The full list of nominally significant associations (i.e., with uncorrected p < 0.01) can be found in Table S2 ].

This interaction remained significant among men ( P = 6.1 × 10 −8 ) but was only nominally significant among women ( P = 0.01).

Phenotypic similarity analysis for locations within the NaV1.2 channel and recurrent variants Phenotypic similarity was nominally significant between individuals with missense variants regardless of location ( p = 0.01, n = 341) and also among individuals with missense variants localized to either the S1 segment ( p = 0.009, n = 18) or domain DIV ( p = 0.05, n = 65).

Male patients with schizophrenia had larger right Hb than healthy male participants but this analysis was only nominally significant at p = 0.01, uncorrected for multiple comparisons.

Simple linear regression analyses revealed nominally significant, negative associations between quality of movement scores and normalized transcript abundances of Cd-associated miR-509-3p (β = −0.47 ± 0.38, p ≤ 0.01) and miR-193b-5p (β = −0.278 ± 0.287, p ≤ 0.1) ( Fig. 3A & B , Table S8 ).

We then tested for interaction with habitual starch intake and observed a nominally significant effect of interaction between AMY1 CN and starch intake on two out of 64 genera, Megasphaera ( P = 0.01) and Acidaminococcus ( P = 0.05), and found similar results when this was analyzed with further adjustments for energy intake, smoking habits, and physical activity level.

Nominally significant associations ( p < 0.01) were detected for several variants in genes encoding vasoactive intestinal peptide receptor 2 ( VIPR2 ), period circadian regulator 2 ( PER2 ), casein kinase 1 epsilon ( CSNK1E ), and activator of transcription and developmental regulator ( AUTS2 ), but no signal survived correction for multiple testing.

In the first, we tested if all nominally significant CpGs ( p value < 0.01) in the three peripheral tissue MWAS (SEED, SSC, and MINERvA) have a shift toward lower p values in the SCDC MWAS (one-sided Wilcoxon rank-sum test).

Of these nominally significant ( p < 0.01) correlations, only age effects survived a stringent control for multiple testing, a finding replicated using the two alternative sleep variability metrics as well.

Enriched GO terms and KEGG pathways were considered nominally significant at a p -value < 0.01 according to Fisher’s exact test. 2.17.

In the adjusted model, this association was only nominally significant [β (95%CI): 0.36 (0.08–0.64), p = 0.01, Fig. 3 A].

Genes involved in the phosphoinositide and the PTEN pathways, as well as insulin receptor substrate binding, was significantly enriched among the nominally significant DMPs ( p < 0.01) we identified in this study ( Table 2 ).

Within LYN-mutant cases, an exploratory domain analysis indicated that distributions differed by CNS status (omnibus χ2 p ≈ 0.014); a one-versus-rest signal at the SH4/Unique N-terminus was nominally significant and borderline after false discovery rate (FDR) (unadjusted p ≈ 0.010; q ≈ 0.052; small in-domain n = 3).

BMI effect on UEC was nominally significant with directional concordance with that in Japanese (β = 4.04 × 10 −3 , P = .010 in IVW analysis). 4.

Variants for which this binomial test was nominally significant (P < 0.01) were deemed to be candidate mosaic variants.

Carriers of the C/T of rs3804099 and rs3804100 of TLR2 had a nominally significant association with decreased HCC risk (OR 0.493, 95% CI 0.331 - 0.736; OR 0.509, 95% CI 0.342 - 0.759) by age and sex adjustment ( P < 0.01) (see Table 3 ) compared with T/T carriers.

We conducted a MR analysis and found that there was a nominally significant association of GDF15 with an increased risk of Alzheimer's disease (IVW: OR: 1.12; 95% CI: 1.027–1.220; P = .01).

A meta-analysis of the respective results for RS-I, RS-II and GOOD revealed that the height association of rs749052 remained nominally significant ( P = 0.01).

We then threshold this z to restrict to nominally significant voxels in which P < 0.01.

We observed nominally significant associations between FUT2 expression and the concentration of three HMOs: 2′-fucosyllactose (beta = 0.12, p = 0.01; Figure S22 ), lacto-N-fucopentaose (LNFP)-II (beta = −0.12, p = 0.03; Figure S22 ), and lacto-N-hexaose (beta = 0.14, p = 0.04; Figure S22 ).

Linear regression analysis provided several nominally significant (p < 0.01) metabolic changes between the two groups in diabetic individuals ( Table 2 ).

The Arg72Pro and cancer incidence For malignant melanoma, the hazard ratio was 0.87 (95% CI: 0.77–0.99) for individuals with Arg/Pro and 0.78 (95% CI: 0.60–1.01) for Pro/Pro versus individuals with Arg/Arg with a nominally significant trend for a per-allele effect (p = 0.01); however, this was not significant after Bonferroni correction for eight tests.