“nominally significant”

To evaluate the association between PRS and CAD, a logistic regression model was used p <5×10−8 was considered statistically significant and P <0.05 was nominally significant.

For VAP incidence, the cumulative z -curve crossed the conventional significance boundary early, indicating a nominally significant benefit, but did not cross the more conservative O’Brien–Fleming monitoring boundary.

Moreover, P < .05 was considered nominally significant, and the selected metabolites could provide an indication of the risk of EC. 2.6.

These early-life exposures are part of the broader childhood exposome, as highlighted in a 2020 study by van der Sloot et al., which investigated 36 factors and identified prenatal smoking as a significant risk factor for CD (OR 1.89; 95% CI 1.38–2.59) and a nominally significant risk factor for UC (OR 1.61; 95% CI 1.16–2.23), even after accounting for smoking in later life [ 107 ].

In addition, rs4601794 again showed nominally significant association with FVIII.

Associations with PP‐values between 0.0125 and 0.05 were considered nominally significant, suggesting potential causal links warranting further verification. 2.6 Confounding Analysis and MVMR Analysis Our analytical validation process included a comprehensive assessment of horizontal pleiotropy and the identification of genetic variants potentially violating core assumptions.

To assess whether our results were influenced by pleiotropy, we performed a sensitivity analysis using two subsets of the original genetic risk score: one excluding SNPs with nominally significant effects on other metabolic traits (HDL and LDL cholesterol, triglycerides, fasting glucose, fasting insulin, HOMA of insulin resistance, HOMA of β-cell function, 2-h glucose, and type 2 diabetes risk) and one including only SNPs found within genes associated with monogenic obesity syndromes ( MC4R , POMC , BDNF , and SH2B1 ).

Although polygenic risk scores for prioritised metabolites showed limited prediction in the UK Biobank, those nominally significant were directionally consistent with MR estimates.

Diseases that were nominally significant across all 6 sites were considered to have significant cultural effects.

In contrast, a nominally significant difference was observed during time window 1 in the sensitivity cohort, a difference that may be an artifact of multiple testing, whereas the lower P value for time window 2 in the sensitivity cohort is stronger evidence of year-to-year change in median exacerbation rates, coinciding with the start of the pandemic.

Nominally significant alterations specific to CD vs control included elevated EM and EMRA CD8 T cells, and Th17 T cells, while classical monocytes (CD14 hi CD16 – ), granulocytes, and basophils were decreased ( Figure 2 E ).

We identify 1 HLA-DRB1 cis- eSNP, rs2516049, with a low Regulome score, significant HLA-DRB1 brain expression association, and nominally significant association with LOAD risk (table e-5).

1985 ) on racehorse performance traits, V PE and V T were also nominally significant in all analyses (based on variance components being > 1.96 SE).

While Bonferroni correction was calculated ( p < 0.017), p -values < 0.05 were considered nominally significant for exploratory biomarker analysis to avoid Type II errors in this pilot cohort.

The significance level of p < 5 × 10 –5 was used to denote suggestive sites of relevance at the epigenome-wide level [ 55 ], and sites with p < 0.05 were considered nominally significant.

In most instances combination with non-Chinese datasets was not possible except for one variant showing nominally significant association.

[ 72 ], who showed a nominally significant transmission disequilibrium between an AVPR1a microsatellite (RS3) and ASD, but this association was not significant after Bonferroni correction.

ORs with p -values <0.05 prior to, but not significant at Bonferroni corrected level were considered nominally significant.

In this context, results should be interpreted with caution, as any nominally significant associations (e.g., lung function and height) or associations with large effect sizes (e.g., acetate) may suggest potential safety concerns and require additional replications in larger studies [ 53 ].

We prespecified a single primary confirmatory comparison (pooled objective understanding) and treated all other comparisons as exploratory and unadjusted; nominally significant exploratory findings should be interpreted cautiously and confirmed in adequately powered trials with prespecified multiplicity-control strategies.

Analysis of carriers of a common LRRK2 risk single nucleotide polymorphism provided nominally significant support for a potential interaction between VAMP4 and LRRK2 , which requires replication in larger sample sizes.

3 , 4 None of the nominally significant genetic variants have known detrimental clinically relevant effects on gene function (Supporting Information Table S6 ).

Intriguingly, a nominally significant interaction between the rs1360780 genotype and changes in DNA methylation at CpG 2 of the promoter region was observed.

A nominally significant association between the gene variant and BMI was observed for BDNF rs962369 under the overdominant model.

A nominally significant correlation was found between hypoperfusion in the left IOG and negative symptom, especially “Alogia”.