“nominally significant”

A nominally significant association was observed between rs984222 ( TBX15-WARS2 ) and FPG.

A further SNP, rs671330, in chromosome 6, has a nominally significant p -value in the approximate test (ranging from 0.048 to 0.040 with increased shrinkage), but again this SNP has not previously been shown to be associated with lung cancer risk.

With the exception of white matter volume in the left hemisphere, IDP associations were not significant at the prespecified 10% FDR threshold, though they were consistent in magnitude and direction with nominally significant unadjusted p values in contralateral structures and using two ALS outcome GWAS.

Of these, only one SNP yielded nominally significant p values across more than one pain or HRQoL score.

Improvements were observed across all PROMIS-29 domains, most notably pain, fatigue, physical function, satisfaction with social participation, and depression; improvements in these domains were nominally significant for both guselkumab treatment groups compared with placebo at Week 24.

Tissue-specific expression analysis revealed significant enrichment of associated genes in metabolically active tissues, most prominently in the kidney cortex (P adj -value = 6.30×10−5), with nominally significant enrichment in the gastrointestinal tract (transverse colon, P adj -value = 0.03).

Analysis of individual user-device pairs showed similar results, save for a single nominally significant difference observed for one user (MJ) within one cell category (peripheral blood lymphocytes).

The other two variants also showed nominally significant associations with other lobar volumes.

Of the OTUs that were significant during the neutral water intervention five were among the OTUs with P-values below the 10 th percentile during the alkaline intervention, two of which were nominally significant.

Pathways, such as glycosylation and glycoprotein processes, achieved suggestive significance when the attack data were included and were nominally significant in the data set excluding the patient, with overall patterns and directions of change consistent.

Notably, only MDD and SCZ showed nominally significant correlations with GERD, whereas BIP did not, suggesting trait-specific rather than pervasive genetic overlap.

nificance but were in genes of biological interest, most notably NRG1, which merits further investigation into their potential role in depression and antidepressant response.' Also in the Discussion section, the following sentence should not have been included: ‘In particular, our analyses provided nominally significant evidence of association of SNP rs11624702 in MDGA2 with response in the combined ISPC-AMPS-STAR*D meta-analysis.'

Breathing discomfort There was a reduction in breathing discomfort for tiotropium/olodaterol versus placebo as indicated by nominally significant reductions in both the slope and intensity of breathing discomfort at isotime ( figure 5 ), with similar results seen in the individual studies (supplementary table S3 and supplementary figure S8).

As metabolite classes overall are not correlated, we used the false discovery rate (FDR) 24 to adjust for multiple comparisons with FDR < 0.05 considered statistically significant and FDR < 0.2 considered nominally significant.

Among these nominally significant metabolites, leukotriene B4 was the most markedly elevated (2.8‐fold) (Figure 2C ) in the recurrent flare group; the amino acids creatine, sarcosine, and L‐canavanine were moderately elevated; and the most markedly decreased metabolites were lipids and lipid‐like molecules.

Based on the observed allele frequency of the rs8019381 SNP, the current samples yielded the power of 0.894 for detecting nominally significant results.

In females, we still observed a nominally significant signal in the M3 mask, with a 15.2-fold in odds of severe disease in M3-variant carriers (95% CI: 1.51–153.4).

The utility of this approach is further evidenced by the fact that the 64 GWAS SNPs were enriched in nominally significant eSNPs as compared to a random selection of 64 variants from the entire set of SNPs used in eQTL analysis.

However, we found nominally significant associations in both male and female T2DM patients.

Of all 40 genes identified here, 17 are nominally significant (20 at the P value threshold of 0.1 used in ref. 21 ) and 11 study-wide significant in ref. 21 .

Furthermore, there were only nominally significant differences between LADA and GADA-only LADA cases.

A recent analysis of haplotypes comprising the rs6857, rs2075650, rs769449, rs429358, and rs7412 SNPs mapped to the APOE gene cluster also suggested a nominally significant adverse effect on longevity in carriers of the ɛ3/ɛ3 genotype, that is, independently of the ɛ4 and ɛ2 alleles (Sebastiani et al., 2019 ).

Nominally significant effects can be found in Supplementary Table S2 – S5 .

Although some of the nominally significant associations fully attenuated after adjusting for education, smoking status, body mass index (BMI), and alcohol consumption (Model 2), all of the associations that were significant after multiple testing in the base model (Bonferroni-corrected P < 0.05) remained significant at P < 0.05.

Of these, 291 probesets (corresponding to 283 unique genes) were nominally significant.