“nominally significant”

Of relevance to IBD, the GTEx database also includes a nominally significant eQTL ( p <10 −3 ) with the same direction of effect in sigmoid colon.

Using HOMER’s default parameters, the final number of nominally significant ( p value ≤ 0.001) interactions was 41,833 for the healthy dataset and 357,749 for the PANC-1 dataset.

Although a Kruskal–Wallis test detected nominally significant inter-phenotype differences in age ( p = 0.001), this significance did not survive correction for multiple testing (e.g., using FDR adjustment).

The interaction term of rs1805008:T and latitude was nominally significant in the analysis of Gd-enhancing lesions (interaction- P = 0.001).

Hospitalization The cumulative hospitalization rates were 50.3 (95% CI, 38.2–62.0) per 100 patient-years in the PTX group and 66.5 (95% CI, 50.2–83.6) per 100 patient-years in the matched non-PTX group, and this was a nominally significant result ( p < 0.001) ( Table 2 ). 3.4.4.

These two index SNPs also showed nominally significant associations in both Huoshenshan and Union cohorts (all P < 0.001; Table 2 ).

Among 235 colocalizations with adipose eQTL ( 25 ), 25 (10.6%) also had a nominally significant trait-gene expression association, at an arbitrary P- value threshold of P ≤ 1e−3, despite a sample size of just 859 participants ( Supplementary Table 12 ); 80% of these had consistent effect directions.

DMR analysis did not find genome-wide significant regions, however 359 nominally significant candidate regions were identified, of which the top 10 regions had a nominal p-value <1.0 x 10 −3 ( S3 Table ).

In the non-EA participants (137 cases, 120 controls), rs17538288 remained nominally significant (OR, 2.06; 95% CI, 1.34 to 3.22; P = 0.0012 ) and rs7546189 did not (OR, 1.29; 95% CI, 0.81 to 1.87; P = 0.33 ).

In addition to these previously established findings, we discovered nominally significant heterogeneity in the geographical distribution of haplogroup R1a ( p = 1.2 × 10 –3 ), enriched in Ceded Karelia (15%) and Satakunta (10%) (Fig. 3A ).

We also found a nominally significant association between an exonic variant in ULK1 and triglycerides (p-value = 0.0012).

We also identified 13 nominally significant causal associations for IL-13 against blood levels of other cytokines, of which six passed a Bonferroni threshold of P < 0.00125 i.e., 0.05/40.

The G×G is genome-wide significant for tau , has a nominally significant interaction for Aβ42 ( p = 0.0013), and the pattern of interaction differs for the two traits in a way that creates the rQTL pattern of tau / Aβ42 correlation changes across genotypes (see Fig. 1a ).

In the ‘protein domains’ category tested using the Interpro database as the source, the term ‘epidermal growth factor like domain’ showed a nominally significant enrichment with P = 0.0013, Benjamini–Hochberg false discovery rate corrected P = 0.073.

Neither CIITA nor PARP4 showed association with endometriosis in the GWA gene-based analyses 14 , although CUBN was nominally significant ( P = 1.35 × 10 −3 ).

The CAMK2B gene that regulates CAMKII is a nominally significant DEG in our meta-analysis (wfisher p -value = 0.00138, adj p -value = 0.0619) and is known to interact with the ARC and RAS genes (enriched DEGs), and also ERK/MAPK pathways [ 69 , 84 ].

This SNP was only nominally significant ( p = 0.0014) in the initial analysis; however, there are five SNPs which were significant in both the unconditional and conditional analyses (rs12048743, p = 2.86 × 10 −10 and 2.90 × 10 −6 , respectively).

The sentinel SNP nearby UMOD from our study (rs77924615) is a nominally significant eQTL within NephQTL 76 (a database of nephrotic syndrome human kidneys) in the kidney tubules ( p = 0.0014) and has a non-significant effect in the glomerulus ( p = 0.079).

Rs3745842 major allele (G) was more frequent in cases compared to controls, although the association was nominally significant after multiple testing correction ( p -value = 1.4 × 10 −3 , corrected p -value = 0.081) ( Supplementary Table 6 ). 3.2 LoF mutations in ABCA7 LoF mutations in ABCA7 have been recently reported as main mechanism explaining the GWAS signal and the increased susceptibility to AD.

A human GWAS of opioid cessation reported linkage to the FGF signaling pathway in which the effect of FGF12 was nominally significant (p=0.0015, odds ratio = 1.24) ( Cox et al., 2020 ).

Results Genetic correlations Using genome-wide LD score regression analyses, we found non-significant negative genetic correlation ( r g ) between neuroticism and BMI ( r g = −0.0174 (SE 0.0213), P = 0.413) and HDL ( r g = −0.0216 (SE 0.0244), P = 0.3765) and positive genetic correlation with neuroticism that was nominally significant for CAD ( r g = 0.0919 (SE 0.0289), P = 0.0015), TG ( r g = 0.0367 (SE 0.0182), P = 0.0432), WHR ( r g = 0.065 (SE 0.0269), P = 0.0159), and non-significant for DBP ( r g = 0.0333 (SE 0.0272), P = 0.2209), SBP ( r g = 0.0426 (SE 0.025), P = 0.0893), CRP ( r g = 0.0313 (SE 0.0273), P = 0.2526), CIGPRDAY ( r g = 0.0445 (SE 0.0572), P = 0.4371), T2D ( r g = 0.0377 (SE 0.0337), P = 0.2638), LDL ( r g = 0.0308 (SE 0.026), P = 0.2351), and TC ( r g = 0.0333 (SE 0.0256), P = 0.1936) (Suppl.

Similarly, observed a nominally significant negative association between CMV positivity and CD8+ CD127− Tem cells using %parent ( p = 1.5 × 10 −3 , FDR = 3.5 × 10 −2 ), but not with %total ( p = 0.26, FDR = 0.69) (Fig. 2b ).

In addition, because CD4T and CD8T showed nominally significant associations with hsCRP, we also tested these interactions in chronic pain and found that CD4T, but not CD8T, positively interacted with hsCRP (beta=2.5, p=0.00175; n=820; Figure 1E ) in chronic pain.

SLCO1B1 locus was nominally significant in the UKBB ( p -value = 1.84e−03) and genome-wide significant in the TC response GWAS for which sample size was larger ( p -value = 1.89E−09, baseline adjusted).

In particular, Pcg was significantly elevated in patients with early-stage PD ( p < 0.0001, p adj = 0.0002) and remained nominally significant in drug-naïve patients ( p = 0.0019, p adj = 0.0550), while also showing a positive association with H–Y stage ( p = 0.0128, p adj = 0.0383).