Two-way ANOVA demonstrated significant effects of GluN1 immunization (CA1: F (1,16) = 39.75, p < 0.001; CA3: F (1,16) = 85.68, p < 0.0001; DG: F (1,16) = 33.17, p < 0.001) and D-serine treatment (CA1: F (1,16) = 5.327, p = 0.0347; CA3: F (1,16) = 12.90, p = 0.0024; DG: F (1,16) = 5.665, p = 0.0301), with significant or near-significant interaction effects.
Following FDR correction, we identified multiple near-significant and significant associations ( q < 0.25 and 0.1, respectively; Extended Data Fig. 9b,c and Methods ), particularly when evaluating features from the immune activation/exhaustion and wound healing clusters (dedifferentiated TI-1 in PD-L1 TPS ≤ 1% q = 0.23; immune-activated M-2 in PD-L1 TPS ≤ 1% q = 0.16; macrophage/monocytes in PD-L1 TPS ≥ 50% q = 0.06; hMono3 in PD-L1 TPS ≥ 50% q = 0.11).
To explore the near-significant interaction, analyses of simple effects were conducted.
This near-significant finding indicates emerging long-term benefits, with the lower RR indicating a potential halving of progression risk, though the upper CI approaching unity cautions against overinterpretation.
However, the near-significant change on the socio-practical domain of the ASOR-5 questionnaire for the uninformed condition combined with a large ES indicates that the instructions at randomization worked (since this near-significant difference may reflect differing attitudes based on the information given about the robot).
The near-significant GDP effect indicates that economic context may play a role in shaping youth suicide risk (e.g., through access to education, health care, social support, or cultural attitudes), but the relationship is complex and not straightforward.
Additional or supplementary data With high-throughput data analysis, many publications come with additional data, either as additional information to support the findings, or as supplementary data to show near-significant results.
We also found a near-significant association with the presence of other dog(s) in the family, plus breed type with frequency of walks interaction, also had a trend-like effect on the CCD score.
This near-significant finding nonetheless represents a clinically meaningful nearly 3.5-fold increase in complications among open injuries, with the limited sample size likely preventing the achievement of formal statistical significance.
We also conducted post hoc power analyses for taxa showing significant or near-significant differences.
Even when the fraction of coupled p-MDTA allele pairs at linked microsatellites in the buffalo genome linearly decreases from a value as high as 0.8 at 24.9°S to 0.5 (expected fraction in the absence of selection) at 4.8°N, the probability of observing a significant ( α = 0.05) or near-significant ( α = 0.1) difference in average latitude with a Student’s t -test between coupled and repulsed allele pairs was only 34% and 46%, respectively (60 r LD estimates from 24 locations using 50 randomizations).
An additional gene, ACAP2 , showed near-significant association with coronary heart disease in CRIC EUR.
The near-significant association supports the need for larger prospective studies to confirm this relationship, particularly given the high co-prevalence of both conditions in Chinese pregnant women and the potential clinical implications for targeted supplementation.
The number of mice used was determined based on a pilot study showing a near-significant difference with the same treatments using three mice per group.
Furthermore, formal tests for interaction revealed near-significant effect modification by smoking status (P for interaction = 0.0784).
The result was not statistically significant in multivariate analysis (P = 0.059), the near-significant result suggests that this factor may have some influence on prognosis.
There was a statistically significant improvement in central vertical rearing counts (p < 0.05), and near-significant trends in central path length and vertical rearing counts (Fig. 4b ).
The authors report that long-term CBD treatment significantly delays or prevents seizure onset and leads to a near-significant extension of lifespan, despite no improvement in classical neuroinflammatory or neuroimmune markers.
Logistic regression analysis On univariate logistic regression analysis, no variables were found to have a statistically significant association with achieving the MCID on the mHHS; however, age ( P -value = 0.163) and BMI ( P -value = 0.072) were near-significant predictors for not achieving MCID.
Interestingly, a marker of autophagic EVs, Sequestosome-1 (SQSTM1), was down-regulated at a near-significant level (q-value: 0.017) in the SCZ cell lysates ( Figure S3e ).
While some variables displayed directional or near-significant trends, these patterns do not provide evidence of causal mechanisms nor establish that the CD prompt directly influenced underlying psychological processes [ 64 , 65 ].
Possibly, we failed to find an error rate switch cost in the MDD group because these patients tended to slow down their responses on SEs, resulting in a near-significant RT difference between MDD and controls on SEs.
Significant and near-significant values were used to create a predictive equation for PI size.
Univariate testing of the significant or near-significant loci, on the full sample of 11,683 individuals, was then used to confirm these findings.
Upon graft failure, there was a near-significant increase of IGRP CD8 T cells in the islet graft compared to d15 (Fig. 7d ); this was also the case for IGRP tetramer-negative CD8 T cells (Fig.