Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer.

In all, six genes achieved significance or near significance, defined as a false discovery rate (FDR) threshold of 10% or 25%, respectively (Fig. 1d ).

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Following FDR correction, we identified multiple near-significant and significant associations ( q < 0.25 and 0.1, respectively; Extended Data Fig. 9b,c and Methods ), particularly when evaluating features from the immune activation/exhaustion and wound healing clusters (dedifferentiated TI-1 in PD-L1 TPS ≤ 1% q = 0.23; immune-activated M-2 in PD-L1 TPS ≤ 1% q = 0.16; macrophage/monocytes in PD-L1 TPS ≥ 50% q = 0.06; hMono3 in PD-L1 TPS ≥ 50% q = 0.11).

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Of these subsets, T-cell receptor (TCR) burden was associated with response but did not reach statistical significance ( q = 0.3).

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