A recent cross-sectional nutrigenetic study in a Saudi adult cohort reported a near-significant interaction between TCF7L2 rs7903146 and total energy and saturated fat intake on insulin concentrations, with TT carriers showing greater reductions in insulin levels under lower-energy dietary conditions ( Al-odinan et al., 2025 ).
Female sex was a near-significant risk factor for bacteremia, the association of recipient female sex and bacteremia has been shown in a previous large cohort study in kidney transplant recipients and is most likely relates to the increased risk for urinary tract infections [ 25 ].
There was a near-significant association between FMD at baseline and disease severity assessed as mild/moderate versus moderate versus moderate/severe (p for trend = 0.051, Fig 2 , panel A), but no significant correlations between FMD and either SF-36 Physical Function (p = 0.60, panel B) or steps per 24 hours (p = 0.22, panel C).
They did not report the main effect of mimicry, but report a near-significant positive effect of mimicry on how non-anxious women evaluated the avatar in terms of likeability and friendliness.
While statistically significant and near-significant results were reported, the study did not calculate effect sizes.
However, another meta-analysis of 23 studies (from 3 months to 2 years) showed a near-significant increase in HDL,[ 53 ] probably due to the that longer periods are needed to manifest changes in LCHP diet-induced HDL metabolism, possibly due to the slow turnover rate of HDL particles.[ 6 ] Similar to,[ 47 , 48 , 54 - 57 ] the present study showed a decrease in body weight that may be attributed
That is, for non-viewpoint markers, Egocentric Intrusion had a numerically positive, near-significant effect on rereading rate, and this effect was significantly more positive for cognitive viewpoint markers.
Other phenotypes, such as > 160/≤88 mmHg and > 160/>100 mmHg, showed significant or near-significant associations in several adjustment models but exhibited wider confidence intervals in the final model, potentially due to smaller subgroup sample sizes or treatment bias.
Leaf Rust The genotype of the Ppd-D1 gene showed near-significant association with the percentage of leaf area damaged by brown rust ( Table S7 ).
EDA and antidepressants A cross-sectional study by Weckowicz [ 81 ] found GSR was a near-significant predictor of psychotherapy and drug therapy in depressed patients.
The C2 signature also showed consistent expression differences between patient response groups (CR/PR, SD, PD) in both Ipi Naïve and Ipi Prog cohorts ( Figure 7C ), as well as significant and near-significant associations with patient overall survival in Ipi Naïve (pre-treatment) and Ipi Prog (pre- and on-treatment) cohorts, despite small patient numbers ( Figure 7D ).
Region-of-interest analysis showed that the ACC exhibited a robust within-line association between mGluR5 deficits and premature responses in low-impulsive RLA rats, along with a near-significant relationship in high-impulsive RHA rats.
This near-significant finding may reflect a parallel anatomical aging process that did not reach sufficient statistical strength in the current sample.
No significant trauma moderation effects were found for IL-6 and connectivity after multiple comparisons adjustment (adjusted p s > .05), although near-significant associations before multiple comparisons adjustment are described in Table S4 .
Our IHC finding is also consistent with the near-significant result from Western blot analysis (Fig. 4 A), and since both analyses represent different non-epilepsy control subject tissue samples, it gave us an enhanced confidence that the increased CACNB3 expression levels in mTLE temporal lobe neocortex were a true biological finding.
The coefficient for Mn is −0.5991, with a p value of 0.075, indicating a near-significant negative effect on the inhibition zone, suggesting that higher manganese levels might enhance antimicrobial activity.
[ 73 ] on patients affected by diffuse axonal injury (a subset of TBI seen with blunt trauma to the head) [ 186 ] reported a near-significant positive trend in cognitive outcomes in the group randomised to three 360 mg capsules of boswellic acids per day compared to placebo, for whom spontaneous recovery during the study period did not approach statistical significance.
Metadata categories that returned a significant or near-significant result in adonis tests were further investigated using PERMANOVA [ 42 ] and permdisp tests [ 44 ].
There were certain factors (i.e., mean RASS and fatal ICH) that showed near-significant trends between survivors and non-survivors, and although the study is not primarily designed to compare them, having a larger sample size could have resulted in statistical significance.
For patients only, a near-significant positive correlation between reaction times on AMT trials with slow speed and short distance and the number of completed categories on the WCST emerged (τ = .273, p = .054).
The same logic may apply to the near-significant signal for anaemia requiring transfusion: transfusion exposure may represent more severe illness, repeated phlebotomy loss, inflammation, or prolonged respiratory support rather than an isolated hematologic mechanism.
In the same fraction, we detected a near-significant 22% decrease in the levels of bassoon in APOE ε4/ε4 compared to APOE ε2/ε3 FRGN mice (Supplementary Table 4 ).
When examining these relationships with respect to type of content, we found a significant relationship between PSMU and intent to click on false news, and a near-significant relationship between PSMU and intent to share false news.
Notably, several core clock genes, including BMAL1 , PER1 , NR1D2 , and CRY1 , showed significant rhythmicity in both sample sets, whereas NR1D1 in adult EPSCs ( p = 0.062) and PER2 in fetal EPSCs ( p = 0.065) exhibited only near-significant oscillatory patterns (Fig. 1C and Supplementary Fig. 1G ).
The most striking findings were for ABCA1 , a well-established LXR target, and potentially ABCG1 , which showed near-significant results (Fig.