What is the p-value of both points' significance tests? A p-value of, for example, <=0.1 indicates a near-significant finding, which still deserves to be discussed. - Minor points: a box appears in the .pdf version around line 165.
α 1 -Adrenergic Stimulation of Aortic Segments With 1 μM Phenylephrine In endothelium-intact segments, phenylephrine (PE, 1 nM- 30 μM) caused significantly higher contractions in SERCA2 b/b than in SERCA2 a/b mice with a near-significant shift of the concentration response curve to the left ( Figures 3A,B ).
The near-significant p -value for 3-pts score could warrant further investigation with larger samples or more statistical power. 5.
not improve shock reversal or other clinical outcomes For the overall population of patients with shock post-cardiac arrest, corticosteroids did attenuate inflammation as represented by interleukin-6 levels For the subpopulation of patients with baseline adrenal insufficiency, corticosteroids had a near-significant improvement in shock reversal compared to placebo, though future studies with larger number of patients will be needed to evaluate this population.
In particular, the observation of significant or near-significant increases in diethyl phthalate and several other phthalate metabolites among adolescents who used cosmetic products; the associations of deodorant/perfume use with diisopentyl phthalate, face/body cream use with benzyl butyl phthalate, and face/body wash use with di-n-hexyl phthalate support the possibility that these compounds may enter the body through product formulations or packaging materials.
4 ). Sprague Dawley: 24 weeks – recovery The overall statistical analysis showed a near-significant effect of GMA-SS exposure on DSP, significant effects of GMA-SS exposure on testes weight and interaction of the two factors for testosterone levels.
This near-significant difference supports the reliability of RAS as a practical screening tool in resource-limited clinical settings. 4.1 Comparison with previous studies in Central Asia Our findings fill an essential gap in the existing literature for this region.
To facilitate interpretation and transparent reporting of the results, the following graphical outputs are pre-specified as part of the analytical plan: (a) Receiver Operating Characteristic (ROC) curves displaying sensitivity versus 1-specificity for each individual biomarker showing significant or near-significant bivariate associations with treatment response, as well as for the combined multivariable models (Elastic Net and Random Forest), enabling visual comparison of univariate versus multivariate discriminative performance; (b) a dot plot or bar chart of variable importance scores derived from the Elast
Additionally, a near-significant positive correlation was observed between conscientiousness and PA ( Figure 2 , n = 38; Pearson’s r = 0.36, P 0.03), which also persisted across all PGY levels.
The income variable (up to two minimum wages) was near-significant, with a p value of 0.95 in both analyses, but it is not possible to indicate any association ( Figure 3 and Table 4 ).
A backwards step-wise elimination approach was applied to refine the periodontal indices model, retaining significant or near-significant variables.
While our study focused on the relationship between WSS and aneurysm growth due to the heavy implication of WSS as a driving factor of aneurysm progression, several studies have found significant or near-significant correlation between vorticity and shear concentration and aneurysm growth and rupture ( Sforza et al., 2016 ; Brinjikji et al., 2017 ).
Table S1 Markers showing near-significant and significant association with bFGF-induced corneal neovascularization in the initial C57BL/6J×SJL/J F2 cross.
We found that women with schistosomiasis had a near-significant association with lower set point plasma viral load levels (-0.23 log 10 copies/ml, 95% CI -0.46 to 0.00) while among men with schistosomiasis we did not observe a strong association (0.04 log 10 copies/ml, 95% CI -0.38 to 0.46).
As soon as work-related PC was included in the model, however, the across-wave (T1–T2, T2–T3), reciprocal relations between job demands and disturbed sleep disappeared and only near-significant, reversed relations from disturbed sleep to job demands prevailed.
While our study showed a near-significant effectiveness of posterior wall ablation in PersAF patients, this finding is at best hypothesis generating: this near-significant finding was achieved in patients undergoing repeat (not initial) ablation, with difference in subgroups in terms of baseline characteristics, lesion set during initial ablation, and ablation energy used during repeat ablation.
LLS showed a negative, near-significant correlation with SLA , which confirms that species with cheaper leaves (high SLA ) tend to be better equipped for replacing leaves rapidly than species with more expensive leaves (low SLA ).
These findings were replicated when the analysis was adjusted for BSA with the addition of the mid-RCA segment, which was borderline near-significant (p value 0.051) ( table 4 ).
It was hypothesized that extending the exercise program by 4 weeks would result in sustained improvements across outcome measures, with certain measures like resting blood pressure expected to reach statistical significance at 8 weeks, based on the near-significant changes observed at 4 weeks in our previously published study (Kirk et al. 2025 ).
The issues of small sample size, low minor allele frequency, and lack of linkage disequilibrium (LD) between genotyped SNPs and the un-genotyped causal SNPs present challenges to detecting truly causal variants among near-significant genetic associations.
In the age groups analysis, for the first age comparison (i.e., age above and below 40 years), only ICP showed a significant difference ( p = 0.048) between the two groups, with AMP having a near-significant p -value of 0.065227, as depicted in Table A3 of Appendix A .
This near-significant relationship suggests that access to green spaces may enhance food security within local communities.
Regardless of the cutpoint determining method implemented, both WL and SUV Max status demonstrated significant or near-significant associations with survival when the alternative variable was held constant.
Multivariate analysis and predictive value of progesterone: Given the significant differences or near-significant trends in BMI, LH levels, and the number of embryos transferred between the groups, a logistic regression analysis was performed to adjust for these potential confounders.
Specifically, this near-significant interaction in our model between PPB and PSA lent support to the hypothesis that an increasing PSA level led to a higher risk of PSA failure, when PPB was less than 2/3.