“near-significant”

The moderate level evidence suggested that there was a near-significant difference with more patients reporting tolerance in the LRD group (RR, 1.06; 95% CI, 1.02–1.11; P = 0.00).

Applying our method to a dataset from the Ludwigshafen risk and cardiovascular health study, we discovered a pair of SNPs with a near-significant interaction ( P = 2.2 × 10 −13 ), in only 1.5 h on 10 processors.

After re-fitting the most significant SNP (OCU4:13,434,448, p = 1.31e-12) as a covariate, another near-significant SNP (OCU4:11,344,946, p = 7.03e-07) was still present.

First, we found SYT1 as a near-significant ( P = 3 × 10 − 6 ) top sweep candidate in the YRI population, featuring both m ^ = 2 sweeping haplotypes and m ^ = 2 MLGs involved in the sweep at the window of maximum signal for K = 20 ( fig. 5 and supplementary fig.

Two QTL with near-significant p -values ≤1 × 10 − 5 were located on Chromosome 2, including a Ser/Thr receptor kinase-like protein and a spectrin repeat-containing CHUP1 homolog involved in chloroplast movement and anchoring to the plasma membrane.

In the same region, we identified several markers near-significant ( p < 0.0001) for crown rust reaction and severity and one marker significant for days to anthesis (GMI_ES03_c7453_413).

In contrast, rs4304220 on chromosome 7 (6,243 SNPs) showed borderline significance: it was significant for RSB ( RSB =3.55, -Log 10 P -value=3.71) and near-significant for XP-EHH ( XP-EHH =1.33, -Log 10 P -value=1.04), also with positive values pointing to recent positive selection in the HC group ( Fig. 3 B).

Significant or near-significant differences were found in the localization of the primary tumor (extrapelvic localization 86.4 vs. 61.6%, p = 0.0002) and the rate of applied MA (13.6 vs. 24.2%, p = 0.0686).

The individual components of queenness, ovarian development and dominance were also significant or near-significant predictors of SVM classification individually (ovarian development: slope±SE = 0.0426 ± 0.0113, p = 4.0 × 10 −4 ; dominance: slope±SE = 0.0231 ± 0.0122, p = 0.06).

Besides, the left ITG showed a near-significant partial mediating effect between Leptotrichia and cognitive impairment (the total effect β = −0.73, p < 0.001; mediation effects β = 1.79, p = 0.072), while the centile score of the cortical thickness in the left ITG was a significant negative predictor of cognition ( β = −0.41, p = 0.045).

Given the high degree of collinearity between SSmallAV and STermAV in both cohorts, and the fact that each variable demonstrated independent or near-significant associations with mortality in multivariable analyses (SSmallAV: p=0.001 in OSIC; STermAV: p∼0.05 in both cohorts) ( table 2 ), we elected to combine them into a single metric, SPAV.

To explore the near-significant interaction, Tukey HSD post-hoc analysis revealed significant differences between bilingual preschoolers ( M = 5.82) and bilingual school-age ( M = 8.43), p < 0.001, and bilingual preschoolers (M = 5.82) and monolingual school-age ( M = 7.92), p < 0.01.

Three variables showed significant or near-significant associations with improvement: length of hospitalization ( p < 0.001), number of siblings ( p = 0.015), and planned pregnancy of the mother ( p = 0.050).

The origin of the near-significant three-way interaction from the overall analysis was therefore, the dominant data, in which the significant main effect of modality F(2,44) = 10.690), p = 0.001 was modulated by a near-significant interaction with experiment F(2,44) = 8.169), p = 0.07.

Results In comparison with placebo, ginger supplementation resulted in significant or near-significant reductions in the frequency (-23.63 ± 5.36 vs. 14.81 ± 2.78, P < 0.001) and severity (-24.15 ± 5.10 vs. 11.39 ± 3.23, P < 0.001) of constipation, the frequency (-12.41 ± 3.75 vs. 3.75 ± 1.82, P < 0.001) and severity (-13.43 ± 4.91 vs. 6.88 ± 2.69, P = 0.001) of nausea, the frequency (-9.31 ± 4.44 vs. 1.56 ± 4.05, P = 0.098) and severity (-11.57 ± 5.09 vs. 3.97 ± 3.99, P = 0.047) of bloating, and the severity of abdominal pain (-5.69 ± 3.66 vs. 3.43 ± 3.26, P = 0.069).

The pattern of correlations between outcome measures at time point 2 revealed statistically significant or near-significant negative correlation between the PHQ instrument and the CD-RISC instrument ( r = -0.611; p < 0.001); and the PCS subscale of the SF-12 instrument ( r = -0.437; p = 0.054).

Rearing events also showed significant or near-significant increases when analyzed separately within binned intervals (0 to 10 min, P = 0.002; 10 to 20 min, P = 0.046; 20 to 30 min, P = 0.074) ( Fig. 3 C ).

Kaplan–Meier survival analysis demonstrated a near-significant ( p = 0.0530) association of PFS with HLA class I expression detected by the HC10 antibody and a highly significant association ( p = 0.0025) with HLA class II expression ( Figure 3 a,b).

In primary rat liver hepatocytes, MPEP dose-dependently reduced ATP concentration, producing a near-significant effect at 3 μM and a markedly significant effect at 30 μM ( p = 0.003).

After binarizing data (large values = 1, small values = 0), run tests showed near-significant ( Z = 1.772, p = 0.076) deviation from randomness for gene length and haplotype diversity, while nucleotide diversity displayed highly significant deviation ( Z = 2.938, p = 0.003), revealing a near-perfect “small-large-small-large” periodicity.

There was a significant or near-significant correlation between betas for size and array at the within-subject level for OL (Spearman rank correlation: r = .63, p = .003) and CL ( r = .43, p = .058) condition, respectively, showing that the gain in response to the change in one of the stimulus parameters was proportional to the gain in response to the change in the other.

Feces At all three time points, a significant or near-significant enrichment was found in biopterin metabolism (day 7: p = 0.004; day 28: p = 0.055; term: p = 0.010).

Composite lifestyle score The lifestyle composite interaction with negative affect showed a near-significant effect (β = 0.188, p = .004, p(FDR) = 0.053), with a numerically larger effect size than protein intake alone (β = 0.124).

The association of FEP with sex, ethnicity, tobacco and cannabis consumption was assessed using Chi-square tests; all four of these categorical variables showed significant or near-significant effect (sex, p < 0.005; ethnicity, p < 0.07; tobacco, p < 0.00005; cannabis, p < 0.04).

This interaction is suggested, but not substantiated, by the near-significant statistical interaction between these factors: two-way ANOVA, F (1,88) = 8.251, p = 0.0051 for Aβ; F (1,88) = 0.8809, p = 0.3505 for htau; F (1,88) = 3.056, p = 0.0839 for interaction.