“narrowly missed statistical significance”

In the event, Neo-ALLTO showed an absolute improvement of 20 % in pCR rates, and ALLTO narrowly missed statistical significance with an HR of 0.84 (97.5 %, CI 0.70–1.02), which was predicted to be HR 0.83 (Fig. 4 ), potentially owing to too few patients in the relevant comparisons.

[ 24 ] showed that patients with steatosis had higher LSM values, although they narrowly missed statistical significance.

5 In terms of clinical outcomes, two moderately sized randomized trials published prior to HEART‐FID (Ferric Carboxymaltose in Heart Failure with Iron Deficiency) demonstrated a reduction in HF hospitalizations and cardiovascular deaths in both hospitalized and stable patients which narrowly missed statistical significance. 6 , 7 The HEART‐FID trial further substantiated these results; thus, consideration of iron replacement in eligible patients with HF and ID is warranted. 8 , 9 The efficacy and safety of intravenous ferric carboxymaltose (FCM) has previously been demonstrated in multiple disease states (e.g. chronic kidney disease [CKD], inflammatory bowel disease, heavy uterine bleeding, postpartum period) including HF. 7 , 10 , 11 Prior studies with FCM have shown transient, asymptomatic hypophosphataemia.

Although the difference in hyponatremia prevalence narrowly missed statistical significance, the magnitude of the odds ratio suggests potential clinical relevance and may reflect limited statistical power in the high-caffeine group.

In the subgroup without tophi, however, the reduction in SU narrowly missed statistical significance.

The overall antibiotic prescription rate was reduced by more than 10% in the intervention arm; however, this effect narrowly missed statistical significance ( p -value 0.057).

The TXA cohort also demonstrated increased external rotation at 6- and 9–12 months postoperatively, although this association narrowly missed statistical significance.

44 , 45 This maybe the reason behind the fact that improvement in pCR by 20% in the case of the Neo-ALLTO trial, narrowly missed statistical significance in the ALLTO trial (HR 0.84, 97.5 % CI 0.70-1.02). 46 , 47 Selected ongoing Cb NACT studies in TNBC There are several studies evaluating various schedules and combinations of Cb in the NACT of TNBC ( Table 2 ).

Although the latter result narrowly missed statistical significance, the consistency between analyses suggests that CTP was associated with a higher detection rate of peri‐ictal abnormalities compared to MRI.

Though it narrowly missed statistical significance, on multivariate analysis women were 16% more likely to receive a late diagnosis than men (95%CI OR0.84 (OR0.70 to 1.00).

Similarly, although the PRP group had a lower median SGD score than both the NSS and steroid groups, the difference with the steroid group narrowly missed statistical significance.

Efficacy of iCBIT Compared to f2f CBIT Since our primary endpoint narrowly missed statistical significance, the key secondary analysis was tested in an exploratory instead of a confirmatory way.

It should also be noted that the sensitivity analysis for new-onset heart failure narrowly missed statistical significance.

Although the intention-to-treat analysis for overall survival narrowly missed statistical significance, the prespecified per-protocol analysis showed a clear survival benefit (median overall survival 53 vs. 36 months; HR 0.75) [ 80 ].

At week 16 of treatment, there was a trend for insulin resistance to improve in the Jiangtang Xiaozhi group compared to the placebo group, but the change narrowly missed statistical significance.

These associations narrowly missed statistical significance, and warrants further investigation.

Heterogeneity was very high (I 2 = 96.0%, P < 0.001), and the result narrowly missed statistical significance.

Potential contributors to this narrowly missed statistical significance on the primary outcome are a higher placebo response than in the phase 2 study and a generally more refractory patient population (median [range] number of prior or baseline ASMs was 8 [3–27]).

This exploratory pilot study also reported a decrease in baseline/interictal saliva CGRP levels for participants receiving BoNT, although this difference was only observed after the third month and narrowly missed statistical significance when compared to placebo-control group.

Taken together, while these results indicate a direction of improvement, the fact that the primary pooled effect narrowly missed statistical significance, combined with high heterogeneity, suggests that the evidence for a general beneficial effect on PTSD symptoms remains inconclusive in the overall analysis.

However, in the Phase 3 LEAP-002 trial ( NCT03713593 ), the combination narrowly missed statistical significance compared to lenvatinib alone, likely due to unexpectedly strong outcomes in the control arm [ 59 ].

CAR showed a modest advantage (SMD = 0.20, 95% CI: 0.00–0.40), which narrowly missed statistical significance (Fig. 7 ).

Although the dominance × group interaction narrowly missed statistical significance, the medium effect size indicates a trend toward sport-specific modulation that warrants verification in larger cohorts.

Frequent consumption of high-calorie foods nearly tripled the odds (AOR = 3.06, 95% CI: 0.96-9.69, p = 0.056), although this narrowly missed statistical significance.

The worsening of renal function was 1.4% and 2.7% respectively (hazard ratio, 0.50; 95% CI, 0.33 to 0.77).The results of the Phase III PARAGON-HF study showed a 13% relative reduction in the primary composite endpoint of cardiovascular death and total (first and recurrent) heart failure hospitalizations, but narrowly missed statistical significance. 98 Sodium-glucose co-transporter-2 inhibitors (SGLT-2is) have significantly improved HF outcomes in patients with diabetes mellitus type 2 (T2D) and may represent a new therapeutic alternative for patients with T2D at risk for or with HF.