While both sedatives reduced systemic levels of the inflammatory cytokine TNF-alpha ( P < 0.05); only dexmedetomidine reduced the IL-6 response to CLIP, though this narrowly missed achieving significance ( P = 0.05).
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“narrowly missed achieving significance”
Sighted at
p=0.055
In the literature
Mood Positive (PA) and Negative (NA) Affect Regardless of Drink, PA was lower at 4 weeks ( M = 48.06, SE 1.94) compared to 2 weeks ( M = 51.04, SE 1.94), an effect that narrowly missed achieving significance [ F (1,15) = 4.27, p = 0.057].
Similarly, Receptive subdomain scores were significantly higher than Written subdomain scores ( p ≤ 0.05), while the comparison between Expressive and Written scores narrowly missed achieving significance ( p = 0.06).
In addition, the 30-s STS test narrowly missed achieving significance in the strength group.
A second immune-stimulating fusion candidate, Granulocyte-macrophage colony-stimulating factor (GM-CSF), induced high neutralizing responses in select animals but narrowly missed achieving significance.
Moreover, all statistically significant associations remained unchanged, apart from the risk of new-onset HF (HR, 0.757; 95% Cl, 0.570–1.005), which narrowly missed achieving significance.
Similarly, mean SU reductions were significantly higher for SEL-212 vs pegloticase (−7.32 and −4.89 mg/dl, respectively; P = 0.0185) in participants with tophi during months 3 and 6 combined, but narrowly missed achieving significance in those without tophi ( Supplementary Table S6 , available at Rheumatology online).