“modestly significant”

Entropy of the age-loss CpGs had a significant positive correlation with BWF ( Figure 3i ), but was not associated with diet, and also had a modestly significant inverse correlation with median lifespan.

A Cox proportional hazards model showed modestly significant effects of GA after adjusting for the effect of NICU units and sex ( Table II ; available at www.jpeds.com ).

When several trials were combined, a modestly significant lower cancer mortality was found in the subjects receiving vitamin D supplements [ 65 ].

While large registry-based studies have shown modestly significant associations between type 1 diabetes and several autoimmune diseases other than type 1 diabetes in the family, we could not observe such associations, suggesting that even large cohort studies cover too small a population to demonstrate a robust association with rare diseases [ 32 ].

[ 19 ], who found a modestly significant correlation (however, this was not confirmed by biopsy in their study).

Modestly significant genes with support from only one of GWAS, TWAS, or RVA were filtered out by CMA.

Exposure to DD did, however, reveal a modestly significant effect of microbial status on a core feature of the circadian system: a longer period (τ) among GF mice.

G) Although we found a modestly significant interaction between control and staurosporine-treated slices, post-hoc multiple comparisons confirmed no significant increase in GCaMP6-filled neurons due to staurosporine treatment (Two-way ANOVA, interactions: F(9, 90) = 2.18, p < 0.034, Treatment: F(1, 10) = 0.041, p = 0.93, Sidak’s test for multiple comparisons p > 0.05). aCSF: 5 slices; staurosporine: 8 slices.

In contrast, trans -acting signals are more modestly significant and often are not replicated (reviewed in [7] , [17] ).

We found a modestly significant correlation between the values of the log( s ) and the OSI in the present study.

Other conditions with modestly significant positive and negative associations are shown in figure 5 and online supplemental file N .

Along these lines, we acknowledge that, several, if not all, of the identified signals in our study might still be false positives and thus the interpretation of the modestly significant associations should be conservative.

While the number of COL3A1 mutant tumors is small, the decreased survival is modestly significant across a variety of statistical analyses.

We also observed a 1.02 fold enrichment of H3S10ph on the female X chromosome, but this difference was only modestly significant (Figure 3C, I ).

In Figure 12 (right), for infants possessing NNS results already considered to be in the normal region (quadrant I) before the frenotomy (cases 9, 22, 43, and 73 (in red boxes)), there were modestly significant improvement for cases 9 and 43 towards the mean of the population in our study and no significant change to cases 22 and 73.

However, Structure analysis with K > 3 provides only modestly significant improvement in the model, and ancestry estimates become unstable.

Similarly, in fully adjusted Model 3, the association remained modestly significant, the OR was 1.06 (95% CI 1.01–1.11) regardless of age, sex, smoking, systolic BP (SBP), total cholesterol (TC), TG, FPG or DM2, BMI or WHR, education and alcohol intake ( Table 2 ).

Discussion In this large, population-based study of older women with a history of oral bisphosphonate exposure we observed that use of denosumab was associated with a modestly significant 13% decreased risk of subsequent breast cancer.

The areas under the ROC curve (AUC) of BMI, WC, and WHtR where all modestly significant (all AUC ≥0.65) and nearly identical at 0.6592, 0.65, and 0.6724, respectively.

Consensus from recent meta-analysis is that there is a modestly significant increased risk associated with development of pancreatic cancer for cag-A -negative H. pylori strain[ 9 - 11 , 39 ], with positive correlated adjustment factors including non-O blood type[ 37 , 43 ] and active smoking status[ 34 , 36 ].

However, we observed a modestly significant increase of the number of Sox-2 + cells that was accompanied by a small but non-significant increase of the total number of cells ( Fig. 4 G).

Within the four temporal lobe alterations observed in probands, only the left STG showed modestly significant familiality.

The association between diabetes and change in delayed word recall from baseline to F1 and to F2 was not significant in models 1 and 2, but became modestly significant in the fully adjusted model 3.

The exclusion criterion for the backward selection process was set at p ≥ 0.10, to avoid excluding modestly significant variables.

We found a modestly significant increase in the dose–response association in relation to cataracts in workers born before 1960.