“modest significance”

Although our analyses identified several AML-related TFs such as PU1, C-Fos, YY1, some of the other AML-related TF regulators such as p300 and C-Myc [48] exhibit either no or rather modest significance (e.g., -statistic 7.58; p-value 0.0059; FDR 0.15 for C-Myc) based on our analysis, which may indicate an over-stringent cutoff (FDR 0.1) used in the feature selection procedure or the intrinsic difference between the mRNA expression and the cognate TF activities.

( 1 ), which includes growth in confirmed cases, country-level control variables and weekly fixed-effects dummy variables, show that growth in confirmed cases variable has a negative and weak significant impact on the Islamic stock market returns (at 10% significance level and 0.010 as highest coefficient) for the initial sample and first sub-sample, while its impact is also negative but with modest significance (at 5% significance level and 0.011 as highest coefficient) for the rest of sub-samples, namely second, third, and fourth.

However, it should be noted that the interaction effects of interest were of modest significance (i.e., just below the 0.05 threshold).

The significant increase in mice eliminated the modest significance seen in our previous publication ( 8 ).

The former analysis will detect significant association in genes with a single strong signal, while the latter analysis will highlight genes with several independent signals, even if each of these is of modest significance individually.

dorsalis within core- Notamacropus rejected only at modest significance levels (P values from 0.079–0.334).

Across the three comparisons, we observed downregulation of processes related to ‘extracellular matrix organization’ and ‘cell adhesion’, although these terms reached only modest significance in our cohort, likely due to the narrower focus on DT-G1 meningiomas.

However, it is important to point out the modest significance of the results, especially in view of the small number of cases.

After adjusting for missing storms, the century-scale decrease in USA-striking HU fraction is weaker and of modest significance, largely reflecting the influence of a maximum in the 1910s (Fig. 3 ).

Notably, our small sample size may lead to modest significance levels, thus large-scale prospective studies are needed to better assess potential associations between clinical characteristics and trends in HbA1c and DEB among adolescents with T1D following the implementation of insulin pump therapy.

Modest significance between a coding SNP of PPARγ and PsA patients has been observed [ 9 ], suggesting that angiogenesis may be an important area of investigation in PsA.

Same way the test results for patient background yielded a P value of .04 (2-tailed) with U of 1732 and a mean rank of 64.18 for novices and 76.42 for experts, suggesting a statistically significant difference between the 2 groups, albeit with a modest significance level.

Since FCRL3 nsSNPs demonstrated modest significance and was later confirmed as a GD susceptibility locus, other borderline signals in this study have since been investigated.

Tumors with loss of the other miRNAs showed a modest significance for this region (hsa-mir-137; Fig. 6 B ) or no significance (hsa-mir-23b; data not shown).

In contrast, it showed modest significance in 3-month period (RR = 1.37, 95%CI = 1.06–1.75, I 2 = 98%, 5 studies, 4058 studies) ( S7 Fig ), 6-months (RR = 1.37, 95%CI = 1.03–1.83, I 2 = 99%, 9 studies, 8303 participants) ( S8 Fig ), 12 months (RR = 1.46, 95%CI = 1.17–1.82, I 2 = 98%, 10 studies, 8438 participants) ( S9 Fig ).

In the presence of salient sociodemographic, clinical, and disease severity covariates, those with an independent relationship style had a 20% increased risk of death compared with those with an interactive relationship style, the model demonstrating modest significance (HR 1.20 [95% CI 1.01–1.43]).

1 ), but the strongest interaction involving this SNP was of modest significance (rs609203 × rs4848623; follow-up interaction p -value: 0.0026; data not shown).

Power to detect true association for disease prevalence of 11%, risk allele frequency of 20% and relative risk of 1.5 at a modest significance level of 0.05 was 0.9 ( http://csg.sph.umich.edu/abecasis/gas_power_calculator/index.html ).

Therefore, our results, especially for factors with modest significance levels, should be considered hypothesis-generating rather than definitive.

Interestingly, however, G114E did rescue docking with modest significance, and notably, D184W elicited a highly significant rescue of BB depth compared to knockdown (Fig. 4F–H ).

Given the modest significance of our findings, further research is needed to confirm these suggestive associations.

Conflicting reports have been published for the association of telomere length with renal disease, however, most publications, albeit in relatively small sample sizes with modest significance values, report that shorter telomere length is associated with renal dysfunction.

The six LA scores listed at Table 4 show only a modest significance individually, but collectively they are significant with p-value of 0.0064.

A follow-up study in another independent sample of schizophrenia cases and controls from the Ashkenazi Jewish population replicated the women-specific association with schizophrenia of rs7341475, although with very modest significance [27] .