“modest significance”

28 However, we did find 4 increased genes that have been identified as GWAS hits of modest significance for sporadic PD by other smaller studies—3 higher among the dorsal SNpc neurons: MMRN2 (multimerin 2), 48 ANXA1 , 49 and B2M (beta‐2‐microglobulin) 50 ; and 1 higher among the ventral SNpc neurons: AGTR (angiotensin II receptor type 1). 51 Although RNA‐seq is a very powerful technique, some technical artifacts may be present in the data (eg, starting concentrations or cDNA quality), and validation with an independent technique is therefore advisable using different biological replicates from the same population.

On the basis of candidate gene studies or modest significance levels in previous GWASs, researchers have proposed associations for many genes with PD to date.

The sequence of the spacer appears to be less critical, although it has a modest significance (B mutation in Fig. 4 A,B).

The results show modest significance, with AUC values ranging from 0.6 to 0.7, and accuracy ranging from 70% to 72%.

Indeed, the association between BLLs at age 1 and HAZ at later ages (2 and 4 years, where more children were stunted as compared to age 1 and 6 years) shifted towards modest significance (data not shown).

Motivations: Professional versus Jury-Determined Standards Before delving into those specifics, I step back to reflect on why Stewart and Peck appear this concerned about a provision that, by most accounts, addresses a technical issue of only modest significance.

The role of structural variables exerts a constructive impact on bridging the financial depth gap, albeit with modest significance.

They found that there was no significant relationship between BMI and orthorexia for physiotherapy students, whilst the dietetic students demonstrated modest significance, with higher BMIs being associated with a higher degree of orthorexia prevalence.

Significant inverse association was observed between total plasma carotenoid concentrations and oxidative stress measured by urinary 8-hydroxy-2’-deoxyguanosine (8-OHdG) while only modest significance was shown for 8-iso-prostaglandin F2α (8-iso-PGF2α).

Only modest significance was found in the acquisition of health information for the health literacy dimension, and possible explanations did not have sufficient statistical power to identify any health literacy effects in this cross-sectional survey or imply that other factors or pathways need to be explored in further research.

Prior studies examining HSP90α in plasma of patients with COPD ( 35 ) demonstrated an increase with disease severity of modest significance, suggesting that HSP90 levels may not be as sensitive and specific for disease.

Betweenness centrality derived from AECs also shows marked increases within the SOZ in the gamma frequency band, but corresponding Z-scores relative to permutation test distributions only reach modest significance in the gamma band.

It is possible that the modest significance derived on linear regression with severity is a reflection of such a phenomenon.

Fourth, the associations with gene expression involve healthy participants and have relatively modest significance levels.

Comparing total activities across all domains of GPAQ with accelerometer-moderate activity ( R = 0.40) and with accelerometer vigorous values ( R = 0.24), modest significance was found.

We included all NEFAs simultaneously in our statistical analyses to minimize the number of separate models fit, but as with any study that examines multiple FAs, we cannot exclude the possibility of chance findings, especially for those associations that were of modest significance.

When using the COVID-19 HG data, we successfully replicated only one of 11 candidate associations (rs33985936 in SCN11A ) which showed modest significance in the analysis of COVID-19 patients vs. population (C2 comparison in COVID-19 HG).

In the genes ABCC9 (LocusLink ID 10060) and LIPC (LocusLink ID 3990), single SNPs of modest significance were associated with disease status in the case control and therefore are not discussed further here.

It is anticipated that most disease-phenotype associations of complex traits are likely to be of modest significance, with OR <1.5 [ 52 ].

Representative maps of the pathways that showed modest significance and were included in Table 1 and Supplementary Table S11 , available at Carcinogenesis Online, such as ‘E-cadherin signaling and its regulation in gastric cancer (FDR = 0.004 and P < 0.001 for Cluster B1)’ and ‘Development_Regulation of EMT (FDR = 0.002 and P < 0.001 for Cluster B1)’, are illustrated schematically in Figure 4 using MetaCore software.

However, CD2 co-stimulation could increase CD16-triggered responses also in the NKG2C − CD57 + subset (both FcεRγ + and FcεRγ neg ) although a modest significance was reached only in NKG2C − CD57 + FcεRγ pos cells (Figure 6 C), although CD2 expression levels were lower than those found in NKG2C + NK cells (Figure 4 ; Figure S4B in Supplementary Material).

The updated interactomes, integrating the latest genetic findings of PD and SZ, recapitulated the groups of genes following the temporal profiles and disease affiliations of DGN2 and DGN3 with high significance and that of DGN1 with modest significance (Supplementary Note S 7 and Supplementary Fig.

32 – 33 The variables nominally associated with the MAPK14 variants within the dyslipidemia subgroup need to be interpreted with caution due to the modest significance levels and small number of carriers, but are provided for descriptive purposes.

By contrast, 3’SS in general did not appear to play a major role in intronic C/P in the samples analyzed in this study, except for some modest significance for the last introns containing upregulated pAs by siSF3b155 and siU2AF65 ( Fig 3D ).

It is good to see that BID was associated with at least modest significance in heart tissue in CARDIOGRAM.