“modest significance”

Modest significance between a coding SNP of PPARγ and PsA patients has been observed [ 9 ], suggesting that angiogenesis may be an important area of investigation in PsA.

On the other hand, the addition of 10 wt % of PEF to neat PLA produces an uncompatibilized blend with lower mechanical properties than neat PLA, although the partial overlapping of the dispersion bands suggests a modest significance of this difference ( Figure 9 a,c,e, J = 0 phr).

Second, due to the lack of earlier studies in this setting, the design of our study, and limited sample size, the conclusions drawn are limited to associations with modest significance.

The major limitation of our study is a relatively modest significance of the observed effect of the candidate locus for this study does not exclude the risk of false positive results due to multiple testing, well below the significant threshold commonly accepted for statistical significance in GWAS, i.e., 5 × 10–8 which is related to the relatively small effect size and small size of the study cohort, as well as relatively high number of patients lost in follow-up.

28 However, we did find 4 increased genes that have been identified as GWAS hits of modest significance for sporadic PD by other smaller studies—3 higher among the dorsal SNpc neurons: MMRN2 (multimerin 2), 48 ANXA1 , 49 and B2M (beta‐2‐microglobulin) 50 ; and 1 higher among the ventral SNpc neurons: AGTR (angiotensin II receptor type 1). 51 Although RNA‐seq is a very powerful technique, some technical artifacts may be present in the data (eg, starting concentrations or cDNA quality), and validation with an independent technique is therefore advisable using different biological replicates from the same population.

Our results suggest also that independent genetic markers need not necessarily be separate genetic variants; those can also be synthetic variables composed from epistatically interacting individual markers that alone do not reach even the modest significance level.

Sst1 S , 62 were immunoglobulin genes, 62 were annotated as pseudogenes, and most differences are only of modest significance ( Figure 4E ).

The authors suggested that e-cigarettes have modest significance to smoking cessation in smokers with schizophrenia spectrum disorders and concluded that their preliminary findings should be investigated in larger samples.

It has been shown that malaria pigment in the placenta is associated with the maturation of cord blood myeloid and plasmocytoid DCs (innate immune cells triggered by TLR7/8 agonists [ 11 , 30 ]), which may explain why cytokine responses to TLR7/8 stimulation were significantly enhanced in past PM (as well as in chronic PM, although with modest significance possibly due to the smaller sample size) compared to the other PME categories.

Heart disease (14.3% vs 4.9%, p = 0.063) and pneumonia noted by the admitting clinician (9.7% vs 4.1%, p = 0.054) modest significance.

However, it should be noted that the interaction effects of interest were of modest significance (i.e., just below the 0.05 threshold).

The presence of elevated SBP at the time of hospital discharge after a stroke is a strong predictor of early recurrence.[ 39 ] Uncontrolled DM has also been shown to be significantly associated with stroke recurrence in WASID study.[ 34 ] Although the presence of hyperlipidemia reached modest significance for recurrence in our study, its control was not significantly associated with a reduction of recurrence.

This returned 5 SNPs that showed modest significance with the phenotype.

Management rationale Overall, the patient had presented with symptomatic de novo LV systolic dysfunction in the background of severe, calcific LM disease and concomitant LM-to-LV fistula of modest significance by angiography.

Modest significance was identified during sensitivity analyses for the Parker mobility score and the Harris hip score favoring the IMN.

For instance, we utilized GWAS p -values or fine mapping posterior probabilities: a gene with a very significant association or high causal probability would receive a larger weight α G than a gene with modest significance.

A modest significance in sex was observed with the males having longer colon lengths than females.

The significant increase in mice eliminated the modest significance seen in our previous publication ( 8 ).

Same way the test results for patient background yielded a P value of .04 (2-tailed) with U of 1732 and a mean rank of 64.18 for novices and 76.42 for experts, suggesting a statistically significant difference between the 2 groups, albeit with a modest significance level.

Discussion The results demonstrated that multidimensional attitudes toward ambiguity had a modest significance in affecting subclinical depression and anxiety in non-clinical individuals.

Conclusion The GRS based on 10 SNPs was associated with pediatric-onset T2D in Mexicans and improved its prediction with modest significance.

The modest significance value reflects the small overall effect on AO in the HD population, and this is due to the low frequency of the deletion (0.25%) and duplication alleles (1.9%).

It is possible that the modest significance derived on linear regression with severity is a reflection of such a phenomenon.

This is rather conservative since it is possible that evidence with modest significance from weakly correlated tissues can lead to very significant combined association when their effects get aggregated.

Overall, the unadjusted data supports (albeit with modest significance at most time points) the main conclusion that humoral immunity to tested blood-stage antigens is hampered or delayed by RTS,S vaccination, and this reduction in immunity is extended for years after vaccination.