“modest significance”

However, there are several SNVs more significantly associated with PPP2R2B expression in eQTLGen, and these have only modest significance in the GeM-GWAS ( p -values of ~0.07, see Supplementary Data).

A second measure of demand generation—exposure to family planning messages in the media at the community level—did not have the expected relationship in the multivariate model, only reaching modest significance (p < .10) in Burkina Faso, Uganda, and Kenya with regard to short-acting contraceptive use and Ghana with regard to long-acting method use.

In addition, the humidity of indoor air was lower in houses with AD children than in houses without AD children, with modest significance ( p < 0.1).

Correlations between RF-predicted and real patient survival on held-out samples were in the range of 0.12 to 0.35 for six TCGA cohorts (Additional file 1 : Figure S9) with corresponding modest significance ( p <0.1) for acute myeloid leukemia (AML) and skin cutaneous melanoma (SKCM), and stronger significance ( p <0.013) for head and neck squamous cell carcinoma (HNSC), glioblastoma multiforme (GBM), lung adenocarcinoma (LUAD), and ovarian serous cystadenocarcinoma (OV).

The cluster with higher expression had a better overall survival rate however with a modest significance ( p = 0.14 for METABRIC, p = 0.13 for GSE58812 ).

Variables that were associated with either sleepiness or breastfeeding at a modest significance level ( p < 0.2) were included as covariates in subsequent multivariate analyses.

In contrast, it showed modest significance in 3-month period (RR = 1.37, 95%CI = 1.06–1.75, I 2 = 98%, 5 studies, 4058 studies) ( S7 Fig ), 6-months (RR = 1.37, 95%CI = 1.03–1.83, I 2 = 99%, 9 studies, 8303 participants) ( S8 Fig ), 12 months (RR = 1.46, 95%CI = 1.17–1.82, I 2 = 98%, 10 studies, 8438 participants) ( S9 Fig ).

The former analysis will detect significant association in genes with a single strong signal, while the latter analysis will highlight genes with several independent signals, even if each of these is of modest significance individually.

Tumors with loss of the other miRNAs showed a modest significance for this region (hsa-mir-137; Fig. 6 B ) or no significance (hsa-mir-23b; data not shown).

Since FCRL3 nsSNPs demonstrated modest significance and was later confirmed as a GD susceptibility locus, other borderline signals in this study have since been investigated.

By contrast, 3’SS in general did not appear to play a major role in intronic C/P in the samples analyzed in this study, except for some modest significance for the last introns containing upregulated pAs by siSF3b155 and siU2AF65 ( Fig 3D ).

The significant increase in mice eliminated the modest significance seen in our previous publication ( 8 ).

Sardinia (adjusted P =.19) and Veneto (adjusted P =.20) also registered a modest significance.

Our results suggest also that independent genetic markers need not necessarily be separate genetic variants; those can also be synthetic variables composed from epistatically interacting individual markers that alone do not reach even the modest significance level.

Same way the test results for patient background yielded a P value of .04 (2-tailed) with U of 1732 and a mean rank of 64.18 for novices and 76.42 for experts, suggesting a statistically significant difference between the 2 groups, albeit with a modest significance level.

However, it should be noted that the interaction effects of interest were of modest significance (i.e., just below the 0.05 threshold).

32 – 33 The variables nominally associated with the MAPK14 variants within the dyslipidemia subgroup need to be interpreted with caution due to the modest significance levels and small number of carriers, but are provided for descriptive purposes.

Although no associations with genome-wide significance were detected, two associations with modest significance were reported. rs500766 (g.6508628C>T) in protein kinase C theta ( PRKCQ ) was found to decrease the risk of ACEIs-AE if the patient carries at least one copy of the alternative allele.

An example of such an analysis is [ 7 ], which showed a highly significant difference in survival with a much more modest significance level for a comparison of 30 day mortality.

Modest significance between a coding SNP of PPARγ and PsA patients has been observed [ 9 ], suggesting that angiogenesis may be an important area of investigation in PsA.

dataset, we also found that CG-1 and CG-2 tumors were more likely to experience biochemical relapse over a 5-year period relative to A-Low tumors, although at modest significance ( Supplementary Figure S3 ).

Notably, our small sample size may lead to modest significance levels, thus large-scale prospective studies are needed to better assess potential associations between clinical characteristics and trends in HbA1c and DEB among adolescents with T1D following the implementation of insulin pump therapy.

This returned 5 SNPs that showed modest significance with the phenotype.

A follow-up study in another independent sample of schizophrenia cases and controls from the Ashkenazi Jewish population replicated the women-specific association with schizophrenia of rs7341475, although with very modest significance [27] .

The six LA scores listed at Table 4 show only a modest significance individually, but collectively they are significant with p-value of 0.0064.