“might not be significant”

The following guidelines were followed when evaluating heterogeneity using the I 2 statistic: 0% to 40% might not be significant, 30% to 60% might be moderate heterogeneity, 50% to 90% might be significant heterogeneity, and 75% to 100% could represent considerable heterogeneity ( Higgins et al., 2022 ).

While the individual paths might not be significant, the indirect path itself might be significant due to non-zero correlation between the component paths.

Note that a cluster found using window sampling might be significant, whereas a cluster with identical properties found using a reference region approach might not be significant.

Therefore, I 2 ≤50% might not be significant and I 2 >50% might be significant. 14 Subgroup analysis was performed according to the mode of drug administration or bioavailability for continuous data and using the type of side effects for dichotomous data.