“might be significant”

145 , 146 By way of illustration, increased expression levels of EZH2 phosphorylated on serine 21 and KDM6A and reduced BMI1 protein in E6/E7-expressing human foreskin keratinocytes might be significant for cancer initiation and progression. 147 E7 protein in HPV-31 binds to and inhibits HDACs, thus enhancing viral replication by activating E2F2 transcription. 148 E6 oncoprotein inhibits p300-mediated acetylation on p53 and nucleosomal core histones, which mediates repression of p53 transactivation. 149 Hence, targeting some members of the epigenetic machinery could play a role in controlling HPV infection and/or HPV-preneoplastic or neoplastic changes.

AKT activation by downregulation of PTEN might be significant to keep its neuro-protective effects.

On the other hand, feral populations might be significant reservoirs of genetic diversity for crop breeding ( Farrant and Hilhorst, 2022 ; Gutaker et al., 2022 ; Pisias et al., 2022 ; Mabry et al., 2023 ).

This does not mean that other school factors not studied here, such as school attachment, social integration into the class, etc., might be significant; further analyses of how school factors relate to identity and extremism are therefore desirable.

These shown that upregulation of PDGFRA , VEGF , and bFGF might be significant in regulating angiogenesis in HUVEC exposed to HDP. 2.8.

However, the m 6 A-circRNAs of cashmere goats have been less extensively investigated, and there is still a poor understanding of expression and regulatory characterizations of m 6 A-circRNAs in SHFs of cashmere goats that might be significant for revealing the molecular mechanisms of maintaining SHF cashmere growth in cashmere goats.

This might be significant because previous studies have suggested that adipose deposition is more pronounced in the apex or near the outflow tracts of the ventricles rather than in the free wall (( 7 , 9 , 19 – 21 )).

Communication from the political decision-makers might be significant in terms of convincing them of the effectiveness of the proposed solutions.

With the Sysdimet dataset, it is approximated that one third of the nutrients might be significant for each measured concentration.

Accordingly, and taking into consideration the anxiety levels, it is not possible to affirm that there might be significant differences between the psychological impact in the mid- and long-term.

intratumor heterogeneity) might be significant for the outcome (e.g. in personalized medicine approaches 56 ).

Reimagining could tell us which public spaces contribute to people’s physical or spiritual well-being; how safe businesses are for their employees, rather than only its customers; which places are more consequential for children and their needs; and which spaces might be significant for social practices of marginalized groups.

In reality, because the inferior border of the mandible and the facial artery are very close to each other, if the soft tissue is not protected by sufficient dissection and traction upon surgery, there might be significant damage to the blood vessels.

Such magnetic field and gate modulation of superconducting Fermi arcs open up a new avenue for the manipulation of Majorana fermions, which might be significant to the topological quantum computation.

Even if such receptors represent a minority within the Ni-reactive repertoire, their effectiveness and amplifying properties in skin responses to Ni might be significant.

The included indices are those mentioned individually in other studies or those we thought they might be significant.

Admission to the ICU, intracranial hypertension, and increased neutrophil-to-lymphocyte ratio might be significant factors affecting the response to first-line treatments [ 15 ].

Previous pharmacological studies have found children are less likely to tolerate and/or respond to SSRIs with increased risk of adverse effects [ 64 , 65 ], suggesting that there might be significant differences in brain 5-HT function in pre- and post-pubertal individuals with ASD [ 66 ].

Naringin may result in significantly higher levels of cholesterol metabolites, levels of cholesterol, and bile acids, which are not absorbed in the small intestine.[ 56 ] In general, endothelial dysfunction stage in coronary disease is related with total serum cholesterol levels,[ 57 ] moreover, HDL efficacy to reverse cholesterol transport might be significant for the function of endothelium as indicated in hypercholesterolemic patient that HDL plays a defensive role in endothelial function.[ 58 ] A possible mechanism for lipid lowering effect of citrus flavonoids might be due to its antioxidant effects and due to its inhibition of uptake of oxidized LDL by macrophages, reduced LDL aggregation, and reduced oxidation of LDL cholesterol,[ 59 ] since macrophages play an important role in the early diagnosis.

For example, adjudicating between purposes might be significant for determining the level of safety required: if the benefits of a device used for enhancement would typically be less than the benefits of the same device used for therapy, then it might be appropriate to require a lower level of risk in order for the device to be approved for its enhancement purpose.

In this article, we have shown that there might be significant differences between the particle-parameter estimates from different algorithms or even different runs of the same algorithm.

This should include an explanation of the risk that there might be significant long‐term morbidity (neurological or otherwise) of the surviving twin but that this damage may have taken place already and urgent delivery may be too late to prevent such harm.

They can detect isolates growing organisms not visualized by microscopy and will alert the laboratory of a possible second organism that might be significant in triggering further diagnostic procedures, carrying out broad-based empirical treatment, or introducing antifungal therapy [ 47 ].

Even in cases where there are organic causes, depression, anxiety related to performance, and other sexual disorders might be significant contributing factors ( 10 ).

The key miRNAs, analyzed by high-throughput sequencing, real-time PCR validation, and hierarchical clustering, such as Aja-miR-1, Aja-miR-2008, Aja-miR-184, and Aja-miR-31-5p, might be significant in regulating hypoxia-associated gene expression.