“might be significant”

Furthermore, there might be significant variations in the “dose” of intervention (number, duration, and frequency), which can also impact the extent to which improvements are realized.

In addition, the potential multivalent nature of CBM92 glycan binding might be significant, as it could lead to the formation of protein-polysaccharide networks that may stabilise enzymes in a manner conceptually similar to the use of immobilisation in industry.

There might be significant differences in the perceived severity among perpetrators, victims, bully/victims, and non-involved individuals, and we hope that future studies can explore this dimension further.

They found that even for the same type of procedure, the variation in the dose levels might be significant depending on the above-mentioned parameters.

High expression of TNFα, through NF-κB and p38 MAPK pathways, could downregulate Cdx2 ( Coskun et al., 2014 ), suggesting that there might be significant cross-talk between epithelium-specific and different immune pathways.

The inverse agonist possibly influences the cognitive aspect of nociception in this test, as the stress of injection might play a role in activating the ECS, an effect that might be significant at early, but not later post‐injection time points (Woodhams et al., 2017 ).

Could the environmental factor be a pollutant? Lever suggested that calcium arsenate toxicity related to cotton processing in Lancashire mill towns might be significant in the high prevalence focus in north-west England.

These results imply that the effect of habitual walking on improved bodyweight and body composition in each category might be significant, especially among patients with long ST rather than short ST (Table 1 ).

From another perspective, the large unexplained variance in our models leaves an opening for the possibility that cognitive variables other than executive functions might be significant predictors of hearing difficulties.

Should it not add up to 130 and not 120? - 2.3.2: the information is in the manual, but shortly mention which scales were combined for easier understanding - 3.1: while the IBD prescence is not significant between the basline and 1 year, authors should mention that 10 % is still a modest difference and might be significant when a larger sample size is used ********** what does this mean? ).

Nevertheless, the authors agree with the reviewer’s comment that the differences in the writing characteristics among each HD subtype might be significant or interesting topics to be explored further.

The last phenomenon might be significant at some frequencies only, for large angles of incidence.

Although the risk is deemed low, the use of milk thistle extracts ( Silybum marianum ) with CYP2C8, 2C9, 2C19, 2D6 and 3A4 substrates is best avoided as a measure of caution, as studies remain insufficiently conclusive about whether there might be significant CYP inhibition on a clinical level with the use of this CM 45 – 47 .

Conclusions/Significance Our results indicate that when humans create novel habitats and ecological heterogeneities, they can provide evolutionary opportunities for rapid adaptive niche shifts associated with lineage divergence, whose consequences upon malaria transmission might be significant. pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement yes pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY Introduction Environmental change is a driving force in speciation and the genesis of evolutionary novelty, prompting adaptive variation to emerge by means of natural selection [1] .

Consequently, identifying miRNAs, associated target genes and their regulatory signaling pathways might be significant in elucidating the common biological development of miRNAs and their roles in the pathogenesis of diseases 30 .

Fourth, we did not investigate psychiatric symptoms, which might be significant contributors to sleep problems in the context of the SARS-CoV-2 pandemic.

This might be significant since we have observed overlapping impacts on cilia formation following depletion of ORC1 in zebrafish and in Meier–Gorlin syndrome patients with mutations in ORC1 ( 70 , 84 ).

Social precariousness, geographical distance from the hospital and difficulties of reach both parents ( eg, because of separation, conflict or death) might be significant obstacles limiting sample size.

However, the constraints that arise from the mechanism of ATP synthase on both the Synthesis-First and Hydrolysis-First scenarios require new ideas for continuous pathways in the origin of chemiosmosis, where an understanding of the relationship between archaeal and bacterial ATP synthases might be significant.

Protein–protein interaction analysis of 226 dosage-sensitive genes showed that TP53 , CTNNB1 , UBE3A , EP300 , SOX2 , ATM , and MECP2 might be significant in the development of miscarriages.

These results indicate that blood pressure and SpO 2 combined with temperature event features might be significant indicators of mortality for different timeframes.

Hexokinase I (HX-1) was also released, which might be significant considering the multiple lines of evidence, suggesting that plant mitochondrial hexokinases can modulate PCD through interactions with voltage-dependent anion channel (VDAC) proteins in the OMM ( Kim et al., 2006 ; Godbole et al., 2013 ).

Therefore, the increase of these bacterial groups caused by metronidazole might be significant in the treatment of canine CE.

In our analysis, we focused on the importance of health behaviors with respect to QoL and did not consider some other variables that might be significant.

Furthermore, several phytomelatonin-rich extracts of plant antioxidants such as simple phenols, flavonoids, tocopherols, ascorbic acid, carotenoids, and others, might be significant for maintaining a proper cell redox balance.