“might be significant”

In addition, although the statistical power was low due to the small sample size, the hook effect might be significant in HBeAg-negative patients with qHBsAg > 1000 IU/mL if the sample size was increased.

6) There might be significant species related sensitivity differences.

Second, there might be significant differences between our eCRFs and real-world CRFs in contents and types of data elements.

Even if, in the case of ‘leaf width’, this difference might be significant (highly so if enough samples are used), the high variation within and between individuals would make it impractical to use it for identification of an unknown individual.

Extracellular survivin might be significant for the pathogenesis of inflammation as previously reported in human leukocytes in the context of autoimmune arthritis 56 or asthmatic pregnancy. 57 In its extracellular context, survivin modulates T-cell responses, skewing immunity towards a Th2 response 58 similar to the phenotype observed in obese patients where leptin resistance is developed. 59 Moreover, downregulation of survivin results in a decrease of IL-6 production by human monocytes. 60 Overall, an additional function of survivin in modulation of inflammatory state in obesity should not be ruled out.

The latter filtering step was employed to exclude genes called as significant but with very low expression values, and genes that might be significant by p -value due to large sample sizes but with modest effect size (difference in FPKM).

In this study, a small dataset was used and the added time for preprocessing was not noticeable, but for larger datasets, this might be significant. 3.3.2.

A common feature of the tumor vessels studies is that the investigators focus on microvessel density overlooking other parameters that might be significant, such as the size and shape of the microvessels [ 4 ].

Nonetheless, this indicates that scholarly motivations are a factor that can be associated with better clinical reasoning, opening up an opportunity to research what other motivations might be significant, since to our knowledge there is still a lack in studies investigating the influence of motivations on clinical reasoning.

Sepsis is a continuous process, so there might be significant pathophysiological differences between the different stages thereof.

We were particularly interested in seeing if there might be significant differences among different surrogate-normal groups.

Based on this information, the authors were concerned that the exposure to the adverse consequences of road transport to horses might be significant.

Finally, while the cost of building the artifact shown in Figure 2 might be significant for some users, there is an alternate lower-cost approach that might be suitable for most users.

The protein plays a crucial role in B cell receptor signaling and might be significant for the development of the B cell repertoire as well as mature B cell function. 13 , 14 Furthermore, BLK is involved in the immune tolerance of B lymphocytes, affecting the function of B cells, which may lead to autoreactive or regulatory cellular responses, increasing the risk of autoimmune diseases.

Third, there might be significant differences between objective and self-reported measures of sleep, and this study only included the latter.

These findings further validate our unbiased search method for conserved regulatory elements that might be significant within a related group of genes, as Ets biding sites have been previously described to regulate genes specifically expressed in megakaryocytes (see Introduction).

However, aspects such as cost, energy consumption and ease of operation might be significant disadvantages of this method.

Since Omega has been developed only fairly recently ( Table 1 ), there might be significant improvements in future releases.

Since the pharmacokinetics of 5-FU is more accurately predicted by fat-free mass in addition to total body weight than traditional anthropometric measurements, gender variations in the composition of the body, especially the significantly more significant percentage of metabolically active, fat-free body mass in males ( Wagner et al., 2019 ), might be significant too ( Gusella et al., 2002 ).

A wide body of research has already demonstrated that defense mechanisms might be significant predictors of physical and mental health [ 24 , 25 , 26 , 27 , 28 ], especially under stressful conditions, such as the COVID-19 pandemic [ 29 , 30 , 31 ].

In addition, it was hypothesised that DBP and chronological age might be significant predictors of MDS. 2.

The overlay with the influence of MnS inclusions might be significant.

Hopefully, the information presented in this review might be significant for further preclinical and clinical investigation.

The extensive use of old drugs (particularly in low-income countries and in farming) might be significant for the emergence and selection of resistance to the novel members of the family, becoming a growing source of variation and selection of resistance to the whole family.

Furthermore, several phytomelatonin-rich extracts of plant antioxidants such as simple phenols, flavonoids, tocopherols, ascorbic acid, carotenoids, and others, might be significant for maintaining a proper cell redox balance.