All four of these patients were HCV-negative, splenectomized, and had no family history of atopy, suggesting that environmental and disease-related immune modulation may be significant contributors.
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In the literature
It is unclear how many specimen collections we missed, yet their contribution to the understanding of the geographic and temporal expansion of these ticks may be significant.
The lead SNP may be significant in the GWAS because it is in partial LD with the functional SNP but does not cause a phenotypic change in the RIL population.
Although the exact mechanism behind IOP elevation following ocular corticosteroid administration is not completely appreciated, it is thought to be derived from an increased resistance to aqueous humor outflow within the eye, and understanding the reason behind such a disparity between IVI and STI of corticosteroids regarding IOP elevation may be significant for comprehending their differences in efficacy.
Alternatively, the costs associated with intensive lipid production compared with other forms of biomass may be significant enough to hinder plant growth.
This confirmed earlier studies indicating that the difference in carotid IMT between children with FH and their unaffected siblings may be significant as early as at 8 years of age, that long-term statin treatment (lasting 10 years) initiated during childhood in patients with FH was associated with normalization of carotid IMT progression, and that earlier statin initiation was associated with thinner carotid IMT at follow-up [ 41 , 42 ].
Given the multifaceted regulatory mechanisms of HIPK2 and the complex pathogenesis of OA, we hypothesize that there may be significant associations between HIPK2 and OA pathogenesis.
Furthermore, there may be significant reluctance on the part of patients and physicians to participate.
It should be noted that some negative regulators of axon regeneration, such as KLF4, are upregulated during development in CNS neurons; attenuation of these genes, as with injury-induced inhibitors of axon growth, may be significant adjuncts to driving growth-associated targets (Moore et al., 2009 ).
We do not know how this may be significant.
However, especially in the moderate range of misophonic reactions, this discrimination may be significant.
The operational landscape of modern biobanking is in flux and the ramifications for public trust may be significant.
Decision-making that is not directly related to BC treatment may be significant for patients.
Alternatively, there may be significant differences in the performance characteristics of ELISA kits used to measure galectin-3.
In 2007, the life expectancy was 68.7 years, ( 9 ) and this impact on survival may be significant, and even more, in the developed countries, where life expectancy is higher.
This may be significant because visceral fat appears to be responsible for more of the adverse effects of obesity than subcutaneous fat is.
Finally, 3 to 4 (5%) of the statistical tests performed may be significant by chance.
The decrease in model size and memory may be significant.
2.5 Role of organizational pride and organizational identification as sequential mediators between green HRM and employees’ environmental commitment Reade [ 53 ] noted the wide range of potential antecedent factors and how different factors may be significant in different contexts.
Notably, the small number of publications exploring immune cell volatiles is in contrast of the broadening literature on exhaled breath VOCs on a range of diseases, where the immune contribution may be significant.
The long list of receptors expressed by mast cells and the mast cell mediators that are produced by their ligation have been comprehensively reviewed by others and this review will focus primarily on a few that may be significant in therapeutic strategies [ 18 , 23 , 24 ].
This opening and change in pyrin orientation on ATP binding may be significant in terms of activation, with the requirement of pyrin–pyrin interactions in ASC polymerization.
However, it may be significant that the raters in Sasson et al.’s study made judgements based on ‘thin slices’ of social behaviour, with transcripts featuring only 60 s of speech content.
The ambient space is much larger, the food items may be more patchily distributed, competition between individual cod may be significant, and environmental factors such as light and temperature are varying.
Thus, even without the UTX mutations, anomalies affecting UTX expression levels such as haploinsufficiency and DNA methylation in the promoter region may be significant contributors to cancer formation 9 .