Barely Significant
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“may be significant”

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In the literature

119 High levels of Akkermansia and Methylobacterium in hepatocellular carcinoma tissues were associated with a favorable prognosis, suggesting that Akkermansia and Methylobacterium may be significant prognostic markers for hepatocellular carcinoma. 92 The presence of Methylobacterium within gastric cancer tumors was associated with poor prognosis of cancer patients. 122 In addition, some intra-tumoral microbes, such as Fusobacterium , Pseudoxanthomonas , Streptomyces , Saccharopolyspora , and Bacillus clausii , are associated with the prognosis of pancreatic cancer, 53 , 54 indicating that these microbes may be prognostic biomarkers for pancreatic cancer patients.
While our results suggest that distinctions between these dimensions may be significant for the identification of risk and protective factors for cognitive health in later life, mixed findings point to the critical need for continued clarification of these constructs and their relevance to health across diverse populations, particularly those who have been historically excluded from research.
These may be due to chance, given the multiple comparisons, may reflect changes in the anesthetic approach to participants who were judged preoperatively to be more cognitively vulnerable, and/or may be spurious and influenced by missing data, which though small in number may be significant given the small numbers of events reported in Supplementary Table S4 .