“may be significant”

A peri-umbilical dermatosis may be significant in heralding certain intra-abdominal diseases including neoplasia [ 6 ].

The value of isotonic volume resuscitation prior to the correction of electrolyte abnormalities may be significant, and great care should be taken with a multidisciplinary team to determine appropriate fluid regimens.

Additionally or alternatively, stable differences in investigators’ status, such as scientific pedigree, institutional resources, and/or peer networks, may be significant drivers of persistently higher or lower RCR values.

These cardiovascular effects may be significant (i.e. reductions in cardiac output); however, they are sometimes observed to a lesser extent with slow administration at a low dose in dogs ( 27 , 28 ).

It may be significant that this/r- like gene for cytotoxic function appears to map within a region that controls those cell surface products which are associated with the antigens recognized for cytotoxic function.

The effects of switchgrass cultivation on CH 4 emissions may be significant but are often ignored.

It may be significant that a candidate sodium/chloride-dependent glycine transporter, snf-5 , is enriched.

In the event of large tissue volumes being exposed to hyperthermia, such as soft tissue sarcomas or chest wall recurrences after breast cancer, clinical implications may be significant.

In the literature there is also some evidence that in order to differentiate ULMS, adenomyosis and ULM, the evaluation of the endo/myometrial junctional zone may be significant, especially the vascular pattern between these two types of tissue, as was suggested by Fascilla et al.

It may be significant that, as Sso MCM is from a hyperthermophilic organism, we perform the helicase assays at 50°C.

Thirdly, there may be significant variation between batches from the same manufacturer [ 32 ].

By identifying key genes involved in dietary responses, nutrigenomics may also provide some indications of genes in which polymorphisms may be significant; these genes can then be investigated further in epidemiological studies.

A brief intervention of this type, focused on recuperating an active coping strategy and regaining control, may be significant for ‘pessimistic’ victims, considering that they are more inclined to avoid problems and “give up”, instead of trying to regain control of their lives [ 13 ].

There is a growing concern that phages/GTAs may be significant vectors in the transmission of ARGs, although there is debate on their importance [ 18 , 19 ].

Such pattern renders the Ag(I) site slightly more electron-rich and thus more resistant to reduction, a fact that may be significant on the low antimicrobial activity displayed by 3 (see below).

Similarly, depending on the clinical appearance, there may be significant variance in the histology of secondary syphilitic lesions. 9 Areolar CL is an uncommon manifestation of secondary syphilis.

At present, the safety and regulatory hurdles that will be encountered with the addition of novel immune potentiators and delivery systems to final vaccine formulations may be significant and are still largely ill defined.

Naturally and at any age, there may be significant variations in AMH levels among women [ 12 , 13 , 19 ], however the greatest variability is seen in women aged ∼25 years.

And, while one might think that feedlots would reduce variation among climatic regions given the global trade of grain, factors other than those related to climate may be significant.

However, Novartis reported that IFN-γ secretion varied greatly from batch to batch, suggesting that there may be significant uncontrolled variations in the safety, potency, and clinical effect of these products 4 .

Biological factors may also contribute, and there may be significant interactions between race/ethnicity and SES on infant sleep outcomes.

Even seemingly minor differences between individuals in immune phenotype may be significant in determining relative susceptibility to both pathogenic and autoimmune diseases, as well as responsiveness to less robust drugs and vaccines [ 1 – 4 ].

Since the PET/MRI and CT were acquired in separate sessions, possibly months apart, there may be significant changes in tissue distribution.

The emergency department (ED) has been singled out as an area within hospitals where overuse of this imaging may be significant [ 2 ], potentially contributing to patient harm and rising costs.

Other vital signs and physiological status not included in NEWS such as frailty and mobility (Brabrand & Kellett, 2014 ) may be significant indicators of deterioration in the care home setting.