Barely Significant
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“may be significant”

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In the literature

showed induction of PD-L1 expression by cytokines as interferon (IFN)-γ or other inflammatory stimuli could result in attenuation of TCR/CD28–mediated T-cell activation which may be significant in the regulation of inflammatory or autoimmune reactions. 8 PD-L1, also called B7-H1, is a member of B7 molecules which are involved in the regulation of T-cell response either through stimulation or inhibition. 9 PD-L1 is generally widely expressed in different tissues from different lineages inc
This may be significant since, even though the presence of NETs is associated with increased microbial killing due to the microbial entrapment on these structures formed by extracellular DNA and proteolytic enzymes, their excessive production could increase sputum viscosity, thus allowing for increased colonization by microorganisms and progressive respiratory decline [ 42 , 43 ].