Barely Significant
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“may be significant”

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In the literature

The point may be significant, that the dominant antibody- evoking components of the variant could be determined best against the homologous strain and against strains isolated subsequent to the time of isolation of the strain which was parent to the variant; it seems, therefore, that analyses of antigenic structure which depend upon tests with only strains of virus which were isolated previous to time of isolation of the variant may furnish only partial information, and therefore, may be unreliable.
Furthermore, only healthy subjects participated, limiting the external validity of these findings and preventing our ability to predict whether possible changes in arrival time, or CO 2 sensitivity, as a result of vascular impairments, may be significant enough to be detected using the proposed methods.
Candidate open reading frames D10L (host range), B10R (virulence factor for myxoma virus), B14R (interleukin (IL)-1 binding protein), and B19R (serine protease inhibitor-1) are further candidates that may be significant for the virulence and transmissibility of Congo Basin MPXV isolates [16 , 26 , 27] . 3.5 Immune evasion Numerous mechanisms have been developed by orthopoxviruses in general and monkeypox in specific to evade the host's immune response [32] .
Monkeypox: A comprehensive review of a multifaceted virus.
Infect Med (Beijing) · 2023 · PMC10699692
Perhaps, their primary function is all but a hook―but if so, what other function could this extraordinary organ have? It may be significant that the related genus Anetia has what appears to be comparable paired structures that are much smaller and would not seem capable of providing a similar mechanical function.
These data collectively suggest that CD8+ and CD2+ EVPs may be significant in two respects: 1) CSF EVPs possessing CD8 and/or CD2 may be used as a potential biomarker for viral-mediated neurological diseases such as HAM, and 2) CD8+ and/or CD2+ EVPs may themselves mediate areas of the disease process in infected individuals.