“may be significant”

Finally, although we have clustered various neurocritical care conditions, there may be significant differences across disease states, or based on brain-injury severity, that may influence the pathophysiology and implications of hyperglycemia.

The implemented algorithms work asynchronously and even though the computational demand may be significant to the use of nested loops and complex algorithms such as GA, they do not impact the prediction computation since the algorithms intend to find a minimum of variables.

As there may be significant variation between local estrogen synthesis in addition to uptake of estrogens from the circulation in some tumours, direct measurement of intratumour estrogens is required to assess the potency of AI estrogen suppression in malignant target tissues ( Lønning and Geisler, 2008 ).

The limited size and/or uneven distribution of the pediatric surgical workforce in LMICs and inadequate access to specialized pediatric and critical care services may be significant contributors.

Thus, the results implied that the effects on bat populations of opportunistic predators with innovative hunting strategies may be significant. 5.

8C ), suggesting that this pol δ-dependent lesion bypass mechanism may be significant for the bypass of these lesions in lagging strand templates in vivo .

In this regard it may be significant that UV-irradiation (UVB) creates skin edema and associated inflammatory responses that include local IDO induction (unpublished data).

This suggests that the impact of other pollutants, such as solvents, may be significant, indicating that the air mass was likely relatively fresher compared to the influence of other sources.

This technique is an efficient sampling method to obtain a representative sample from a population with non-overlapping classifications, and the factor classifying the population may be significant on the study parameter.

Apart from environmental and socioeconomic factors, food habits and access to proper healthcare may be significant causes of the increased rates of mortality with AA in various cancers [ 16 ].

Derangements in such mechanisms may be significant in understanding the pathology of placental diseases and aiding in developing treatment strategies.

Although the study questionnaire did not specifically use the term ‘flushing’, questions related to flushing practice and may be significant in discarding unflushed administration lines that still hold antimicrobial medication.

Given that RMR-TB composed approximately 20% of all patient episodes in this setting and 22% of MDR/RR-TB globally ( 24 ), there may be significant potential to simplify or shorten treatment for this group.

It may be significant that we observed a reduction in methionine, asparagine and threonine in the POM cycle strain.

During the initial installation of the equipment, there may be significant drift in the observation data.

Secondary predation is a potential source of error when tracking trophic links (Sheppard & Harwood, 2005 ) and may be significant in copepods owing to their feeding strategy.

Structural changes precede the development of optic nerve head cupping and visual field loss.[ 4 , 5 , 6 , 7 , 8 , 9 ] Changes in nerve fiber layer thickness of 20 μ may be significant interval changes in glaucoma.[ 10 ] Optical coherence tomography (OCT) provides objective, quantitative, and reproducible measurements of the ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) thickness.[ 11 ] Fourier-domain (FD)-OCT has resolution power up to 5 μ in measuring the ave

Finally, up to date and evidence based counselling about the related short and long-term risk should be offered to OD candidates, as in some cases the risk may be significant, and even overcome the benefits ( 137–141 ).

The reasons behind the failures are many, but two of them may be significant: (i) current animal stroke models are mostly conducted using young animals, which inadequately reflects stroke in the aging populations and (ii) the major contributor (s) leading to brain ischemia-reperfusion injury have yet to be completely identified.

We and other researchers have shown that when analyzing a large number of outcome measures (as is often the case in TBI research), there is a high risk of selection bias for reporting only the handful of univariate measures that may be significant ( Haefeli et al., 2017 ).

In addition, depending on an individual employee’s level of technology readiness [ 18 ] and the differences in cultural customs surrounding them, there may be significant learning costs to access HAT.

However, in the intensity-modulated radiation therapy (IMRT) era which has dose density changes, the impact of CVR may be significant.

The reasons for these differences are unclear, but it may be significant that the earlier studies focused on times after CT had induced hypersecretion, a time when there have been long-term increases in the excitability of some enteric neurons (Gwynne et al., 2009 ).

Finally, our results are important and may be significant for other scientist and regulatory affairs working in pharmaceutical industry, especially due to PDE-related topics.

Therefore, adiponectin may be significant in the prevention of atherosclerosis [ 102 ].