“may be significant”

The systemic inflammatory process, hypoxia, and drug use may be significant factors for the occurrence of these symptoms, [ 38 – 40 ] which may also be associated with the development of an encephalopathic condition [ 40 ].

Recent data suggest that such biotic impacts may be significant and that their role in defining population dynamics and fermentation outcomes may have been underestimated.

The ZnA region is able to homodimerize, which may be significant for the E3-ubiquitin ligase activity of RAG1 and/or its regulation ( 14 ).

Furthermore, the interaction between a higher fraction dose of PRT and the interval between PRT and administration of ICIs may be significant in the development of grade 2 or higher RIE.

The extended nature of the Laa1 binding site on Lft1 and Laa2 may be significant for their molecular mechanism.

The transcriptome sequencing of prostate cancer cell lines, nonmalignant growth of tissue next to the prostate, localized prostate cancer, and metastatic prostate cancer revealed that more than 120 ncRNAs in prostate cancer may be significant for oncogenesis [ 127 ].

The route by which E2 is administered may be significant in maximizing CVD risk reduction, as transdermal E2 prescribed during perimenopause had no effect on HDL-C but did reduce HDL-CEC compared with placebo ( 8 ).

These discordant observations suggest there is additional nuance to be explored in this area; perhaps that there may be significant variation in the threshold dose for TREX1 activation in different cancers.

Considering that there may be significant cross-reactivity with the multiple isomers of COX-derived prostaglandins, ELISA may not be the most precise method [ 19 ].

Although food is reported to be the major route of transmission of the pathogen, previous studies [ 8 – 13 ] indicated that Listeria is capable of surviving conventional wastewater treatment process even after disinfection; thus suggesting that wastewater may be significant in the epidemiology of the pathogen.

The different general assessments of daytime and nighttime conditions may be significant using the daytime and nighttime VAS in patients with uncontrolled asthma. 28 Thus, early relief of nocturnal symptoms may improve general conditions faster than daytime symptom relief. 28 Our study showed that SITT efficacy appeared faster than SIDT efficacy for nighttime VAS and ACT scores but not for daytime VAS.

There may be significant implications if the follow-up data of the ADAURA trial and the readouts from the ALINA are very positive, albeit for surrogate endpoints for OS.

This may be significant given that subunit c of the complex is present in 10–15 copies per complex and the alpha subunit is present in three copies while all the other mitochondrially encoded subunits are only present in one copy each per complex V [ 46 ].

By integrating these observations with accurate and rapid monitoring of mining-induced seismic events, along with data on mining progression, there may be significant enhancements in the prediction of mining-induced seismicity.

With a greater geographic range of sampling in the current study, it is clear that geography or climate may be significant as proposed previously.

These characteristics enable frequency distribution changes over time to be examined and specific trends or factors that may be significant for alcoholic EEG signal categorization to be identified.

(3) The definition of csPCa used in this study does not include all clinically significant diseases, in that ISUP GG1 with a high tumor volume load may be significant and ISUP GG2 with a low tumor volume load may be insignificant.

In our study, increased intersubject functional variability was observed in uncinate fasciculus and corona radiata, which extend previous findings that the microstructure of these tracts may be significant neural indicators of individual differences in cognitive domains including emotion and attention (Niogi et al., 2010 ; Pedersen et al., 2022 ).

We performed a large number of analyses and some of the comparisons may be significant by chance.

Whilst the differences in this loop may be significant on a local level, we do not see a possible way for these changes to be transmitted through the protein to the DNA binding site.

Importantly, anemia may be significant in determining the outcome of comorbid vascular disease in DM patients [ 32 ].

This may be significant given the fact that smoking has been shown to influence DNA methylation in a variety of contexts [23] , [24] , [25] , [26] , [27] , [28] , [29] .

Our findings may be significant in understanding this phenomenon of maladaptive response to social stress, as cumulative experiences of humiliation and AS may contribute to their inability to cope effectively with the experience of social exclusion.

Conclusions Our study elaborated on the potential mechanisms of SGLT2i in treating obesity-related AF by methodically predicting, screening, and analyzing targets and pathways that may be significant in biological processes and further validating the findings via in vivo experiments.

Our study suggests that burdens may be significant for some families, and these burdens may serve as barriers to care for some patients.