Barely Significant
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“may be significant”

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In the literature

The findings from the clinician cohort in this survey suggests that there may be significant variability in practice amongst clinicians with regards to DED evaluation and management in relation to CS, and further highlights how the complexity of DED may have limited the development of an overarching clinical approach to its evaluation and subsequent management.
It has been observed that complexation reactions involving biologically active molecules and simulating the processes occurring in the living organisms (for example, enzyme–substrate, peptide–DNA, antigen–antibody interactions, etc.) are accompanied by small negative changes of the free energy, despite the fact that changes in the enthalpy may be significant [ 38 , 39 , 40 , 41 ].
The reduction of asymmetry to below 2 mm may be significant, since in a previous study it was found that only asymmetry (due to proptosis) greater than 2 mm, was noticeable by observers. 31 Further, this study indicates that this balancing of symmetry does not occur during the natural short-term course of the disease.