“may be significant”

This is particularly relevant in the analysis of data from large cohort studies, in which the number of unaffected individuals far outnumber the cases and the number of unaffected individuals with a family history may be significant.

However, we also anticipate that even within the adult population there may be significant variation in characteristics.

In a given case, there may be significant overlap between various entities of diagnostic and therapeutic dilemmas.

Shock and Hemorrhage The shock caused by sudden deposition of gut contents, or infected uterine contents, into the peritoneal cavity, plus the hemorrhage resulting from the rupture, may be significant contributors to the common fatal outcome when an infected viscus ruptures.

However, residual astigmatism after this procedure is common and may be significant, limiting maximal visual rehabilitation [ 8 , 26 , 27 ].

In addition to the consequences on public health, the impact of WNV on animal health may be significant since the equine sector represents a valuable socio-economic resource in rural areas in Europe, and especially in Spain.

This is unlikely to create a substantial gap between actual and estimated emissions for peninsular Malaysia, where plantations have a longer history, but it may be significant for Sabah and Sarawak.

Nevertheless, these diagnostic techniques still have limitations, and there may be significant similarities in radiological features among different types of parotid tumors ( 16 ).

A seasonal cycle of DDAs in a Global ocean model Our simple nutrient competition framework for interpreting the seasonal stimulation of DDAs lacks many other factors which may be significant for fitness, including the two-way interaction between organisms and nutrient fields.

Some symptoms that may be significant in younger patients include refusal to eat or drink, social withdrawal, repetitive movements, and regressive symptoms, such as urinary incontinence ( 4 ).

As with all self-reported studies, there may be significant disagreement on some items (e.g., abilities and skills), where respondents may not always answer the question accurately.

The risk attributable to the overall comorbidity burden may be significant in this context, and the ACCI can be used as a supplementary factor to consider when planning individual surveillance after primary treatment.

62 This is detectable throughout the developing mouse embryo and the placenta, is enriched in the brain in adult mice 29 , 57 , 62 , 78 and may be significant for the development of higher brain functions in eutherian mammals. 79 The neural function of this cluster is supported by recent research suggesting that coordinated expression of these miRNA, including miR-134 and miR-329, is important for brain function and development.

HSPA4, a heat-shock protein found to be also expressed in embryonic stem cells [ 97 , 98 ], has been shown to have a critical role in spermatogenesis, as its lack of expression led to reduced numbers of spermatozoa that bore apoptotic characteristics [ 99 ], suggesting again that the expression of this marker in SBSCs may be significant for their survival.

Chemotherapy turns out to be ineffective in the majority of the ESTS, and toxicity may be significant. 34 , 40 , 41 As expected, administration of chemotherapy with or without surgery and/or radiotherapy declines with age in our series.

less than 0.56) may be abnormal, and in a case involving substantial unilateral RAS, the difference in mean RI between the two kidneys may be significant ( 7 ).

Given that systemic IL-6 regulation alterations may be significant in the establishment of central nervous system lesions [ 82 ], reductions in this cytokine may have substantial clinical outcomes in people with MS.

Development of JAKi with increased activity and/or allosteric inhibition alongside agents with specificity for mutant JAK2 may be significant in the coming years [ 117 , 118 ].

This study suggested that the novel target Dectin-1 may be significant in the development of effective antidepressants with novel mechanism(s) for the treatment of major depression.

The impacts of the alterations in biomechanics and long-term sequelae may be significant with surgical intervention, and conservative treatment may not ameliorate the symptoms immediately ( Hermantin et al., 1999 ; Yorimitsu et al., 2001 ).

While there may be significant barriers to Internet access for certain demographic groups, such as those above age 65 and those with lower education and income levels (Rainie 2010 ), our study indicates that once members of these demographic groups do gain access to the Internet, the potential for the Internet to close socio-economic gaps and racial divides is high.

However, large amounts of oral health data concerning persons with intellectual disabilities are scarce, although these data may be significant for the evaluation of existing policies [ 12 ].

The environmental consequences of these effects may be significant, depending on what ecological roles the microbes play, whether they have many or few ecological relationships, and whether they interact strongly or weakly in those relationships.

However, recent foundational clinical and epidemiological studies indicate that lipid metabolism disorders may be significant factors in cancer occurrence and development [ 76 ], with lipid metabolism playing an essential role in tumor growth.

It is also increasingly being discovered in urban green spaces such as public parks, where the opportunity to encounter and transmit pathogens to humans and companion animals may be significant [ 17 ].