“may be significant”

There may be significant differences between cadavers and live subjects, potentially related to both the advanced age of our cadavers (though by study design, age at time of death was not available to us for patient health protected purposes) and difference in quality of cadaveric tissue, such as bladder fibrosis.

Aggressive neoadjuvant therapy and prostatectomy in patients with metastatic disease represent a promising approach, 13 but there may be significant consequences to the overall well‐being of the patients and quality of life, as borne out by the observed changes in body composition.

28 These data suggest that 1,25(OH) 2 D can have diverse effects on both prostatic epithelial and stromal cells and this cross‐talk may be significant in prostate cancer biology.

Rab1 and Rab18 have a complex history, and paralogous expansion of Rab1 or Rab18 may have given rise to two lineage-specific Rabs, KSRX1 and UzRX3, which appear across the Euglenids as tandem genes and are also present in the heterolobosids; however, it may be significant that in T. brucei these proteins have no obvious role in trafficking ( Natesan et al., 2009 ).

This is compatible with the literature, as other authors have also described that there may be significant reduction in HRQoL after fractures of the lower limb.

Therefore, the heterogeneity of cancer cells and individual differences may be significant and further larger-scale studies are needed.

However, the extent of the remodeling is unknown, which may be significant if a contoured graft no longer matches the curvature of a growing trochlea.

For autistic individuals, there may be significant difficulties accessing face-to-face interventions delivered by clinicians with the specialist knowledge and skills required to deliver autism-specific interventions ( Khan et al., 2019 ).

However, although small, these differences may be significant time savings to individuals in practical terms, and would certainly represent large cumulative time savings over multiple standard setting processes.

Our study demonstrates that considering buffer zone effects explicitly may be significant in the selection and application of conservation and management strategies.

This may be significant, as differences in sex distribution can influence gene expression and craniofacial development, potentially affecting outcomes related to tooth eruption and occlusion.

Conclusions Despite almost universal access to free primary healthcare, there may be significant and highly variable under-diagnosis of CVD across England, which can be partially explained by persistent inequity in GP supply.

It's worth noting that there may be significant differences in the size and composition of TME between different cases of NPC.

It has long been noted that among 46,XX CAH females, while there may be significant overlap in feminine-masculine gender role behaviors that gender identity is usually female indicating that many of the social cues commonly used to indicate gender, such as gender role behaviors, are not closely aligned with gender identity outcomes.

However, a number of organizational characteristics may be significant in preventing and reducing the incidence of work-related stress ( Giorgi et al., 2019 ), including organizational climate.

Importantly, while these food systems may be more adaptable on average, the impacts and adaptive burden would be heterogenous across groups and households, and other economic, social and cultural costs may be significant.

For example, researchers should increase sample size and follow-up duration for event-driven trials, as the power loss may be significant in situations where there is a long duration of delayed separation.

This is not necessarily important if biomarkers are being used for management purposes (such as the identification of sick animals or the assessment of nutritional status) but may be significant if the biomarkers are used as phenotypes for genetic selection for improved animal health and resilience.

While there may be significant public health policy interest in defining preclinical disease using hs-cTn assays, widespread adoption of a clinical screening program will become possible only if a cost-effective and safe intervention is readily available. 2.

The hypoxia-associated factor (HAF) might also promote ubiquitination and proteasomal degradation of neurofibromin, which may be significant during physiological hypoxia including embryonic development and wound healing, but may also play a driving role in the development and progression of hypoxia-associated cancers 148 .

Thus, the pathological consequences of this interplay may be significant, and synergistic, to effects on DA dysregulation, considering that we have shown neuroprotection from 6-OHDA is at least partially an outcome of reduced gene silencing.

This study is an initiative to look at the thoughts of students and teachers and we acknowledge there may be significant logistical limitations to bringing forth changes and few may disagree to our ideas.

This limitation is worth noting because there may be significant differences across China’s provinces and between urban and rural areas in terms of social and economic development, the quality of cancer registries, diagnostic capabilities, and access to treatment.

These vulnerabilities may be significant, particularly in light of blockchain’s immutable nature.

This difference in the distribution of CA repeat length may be significant, because promoters with 21 CA repeats appeared to have a higher promoter activity compared with those with shorter repeats ( Shimajiri et al 1999 ).