“may be significant”

This observation suggests that in patients with high-risk, progressive, or metastatic renal tumors, there may be significant immune dysfunction or immune exclusion occurring within the tumor microenvironment.

( 2011 )], and since it has been less frequently explored in previous research, the role of the fathers in the development of children's fear may be significant [see Bögels and Phares ( 2008 ), for more detail].

The effects of postoperative complications on long-term OS may be significant, but the present study is unable to evaluate these influences given the limited granularity of this large database.

1 , 2 Given the substantial number of people affected, the burden of subsequent interstitial lung disease may be significant.

There may be significant epigenetic heterogeneity at this particular locus, and progression from hypermethylated to hypomethylated MGMT promoter status in recurrent tumors may reflect the selection of existing hypomethylated MGMT cells and serve as a mechanism for further resistance to TMZ [ 25 , 156 ].

It may be significant that human PSGL-1 has three tyrosines in the putative binding region whereas mouse has only two [ 3 , 21 ].

CRIC) rather than single-dose RIC, potentially inducing an ischemic tolerance and targeting athero-inflammation, may be significant in inducing a treatment effect.

Regarding CYP activity in extrahepatic tissues, although the gut is more restricted in its biotransformation capacity in terms of enzymes and their activities, its contribution as the first-pass site may be significant, e.g., for CYP3A4/5 substrates ( Kato, 2008 ).

In other words, 15 L/min of RM added to the HFNC of 40 L/min (increasing flow by 37.5) may be significant in view of the high PIF in respiratory failure [ 12 , 13 ].

The implications of the chloroplast genome type for plant performance are not known but may be significant.

The C-terminal tail of MCT1 is more effective than that of MCT2 in this regard ( Figure 5 A) and it may be significant that the amino acid sequences of these C-terminal tails show little sequence conservation.

This may be significant as the 50‐fold induction of chiC1 against F. graminearum , but not against B. cinerea , may suggest adaptation of killer toxin‐like paralogs towards different fungal preys (driven by differences in cell wall composition, presence of chitinase inhibitors etc.).

The burden of long-term post-SARS-CoV-2 delirium may be significant, particularly for elderly patients who are more susceptible to post-infectious neurocognitive complications ( 13 ).

Although these are banned at our institution, these may be significant cost factors at other institutions.

Many patients will continue to purchase DHEA (or equivalents) which are available “over the counter” (OTC) as nutritional supplements, and physicians should caution their patients that there may be significant variation in the actual DHEA content of these OTC preparations [ 75 ].

It is also morally contentious, particularly in the case with Track 2 where applicants’ years of life lost may be significant.

It is possible that this survival difference may be significant in a larger cohort, as patients with single-site disease are more likely to undergo complete gross resection compared to patients with multiple-site disease.

For example, North Pond energy is primarily from the FeS 2 /O 2 couple ( Figure 4 ), indicating that solid mineral substrates may be significant in this environment.

Such change may be significant since Y448 is nearby to the pore-blocking F450 residue in TM9.

The partial inhibition of the ATPase activity ( Figure 5 ) may be significant and will be discussed below.

The contradiction is resolved if we acknowledge that there may be significant differences in the social characteristics of users depending on how recently they began writing on KS.

In addition, one should examine the isotope-dependence of the dynamics and the influence of high- Z impurities, which may be significant in the tokamak edge.

Whether it is inability to recognize potential risk or lack of proper understanding of exposure to scatter radiation, it may be significant on the basis of cumulative effect or for individual procedures with prolonged exposure such as implantables and intradiscal procedures.

Our preliminary findings on the potential control of breast cancer and metastatic status by using DAS and chalcone combination may be significant from a therapeutic standpoint.

These may be significant contributing factors for treatment and RT-specific refusal.