“may be significant”

This may be significant in processes such as neuronal migration where temporal regulation is fundamental.

This finding may be significant in clinical practice with increasing numbers of immunosuppressed patients in rheumatologic, pulmonary, hematologic, and oncologic populations as a result of solid organ transplants, biologic agents, and chemotherapy.

27 Translational development will require further studies, but this proof-of-concept study confirms that the pseudoexon class of DMD mutations is amenable to U7snRNA treatment and demonstrates the potential of such individualized gene therapies to restore full-length dystrophin expression, which may be significant and durable.

It may be significant that V1 activity has not been observed in these studies, suggesting the possibility that it is dependent upon the “V1-bypassing” input to V5.

Delay of disease progression without negatively impacting quality of life may be significant benefits from SPM.

27 28 Though in this respect it is important to note that ophthalmic data is often relatively complex, and it may be significant that all of the participants in the present study had lived with their diagnosis for many years, and so may feel relatively confident interpreting eye test data.

Survivors, who are still able to work, are forced to stay active in the labor force because the implications of losing their jobs, and ultimately their health insurance plans, may be significant [18;19].

Furthermore, there may be significant interactions between polymorphisms in genes associated with breast cancer, particularly MDM2 and CYP1B1, and dietary soy isoflavone intake.

annua seeds has re-myelinating properties, which may be significant in treating neurological disorders accompanied with loss of myelin [ 25 ].

Furthermore, in trans feminine persons, alterations in pelvic dimensions may be significant for surgical outcomes of vaginoplasty procedures ( 18 ).

For instance, the number of COVID-19 cases may have been increasing or decreasing at a relatively smaller level over a period of time on a daily basis, but, at the same time, there may be significant differences in the number of COVID-19 deaths over a period of time due to better treatments at some stages and also delays in the deaths during other periods. 4.2.

The hazard ratios (HRs) of these seven prognostic NSGs are shown in Figure 2B , indicating that AGAP3 , RUVBL1 , and LRFN4 may be significant risk factors for CRC, while TRAP1 and NME1 may be significant protective factors for CRC.

This may be significant, since supplementation with ω-3 PUFAs resulted in increased levels of EPEA and DHEA in rat brain at the expense of anandamide [ 180 , 181 ] and because the CB2 receptor is thought to signal anti-inflammatory effects in both peripheral and CNS immune cells [ 182 ]. 3.

Additionally, the observed automatic regulatory mechanism may be significant for understanding the integration and functional regulation of transplanted neurons within the host brain.

The timing of immune dysregulation, with respect to gestational age and neurologic development of the fetus, may be significant, as distinct immune and neurodevelopmental programs are affected differently depending on fetal stage.

Additionally, the evaluation of gene expression may be significant in predicting responses to traditional anticancer treatments and determining patient prognosis.

These observations indicate that macrophages may contribute to the outcome of an immune response through mechanisms other than by acting as established NO-producing cells and that their role in determining the resistant/susceptible phenotype in mice may be significant.

Even if the involved ionization processes are quite different, these techniques ensure the efficient ionization of poorly polar aromatic (APPI and APCI) and poorly polar aliphatic (APCI) compounds, amounts of which may be significant in bio-oils, especially after catalytic upgrading treatments.

The two loci have high LOD values and may be significant trait-associated QTNs with breeding potential ( Supplementary Figure S3 ).

This indicates that these regions may be significant factors in the class separation captured by these components (see Table 1 ).

To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ Abstract The effects of sublethal pesticide exposure to honey bee colonies may be significant but difficult to detect in the field using standard visual assessment methods.

The occurrence of weight‐based bullying at school may be significant with respect to the child's eating and exercise patterns, mental health, and willingness to adhere to recommendations.

We hypothesise that host inflammation and environmental factors such as medication or diet may be significant contributors to the altered mucosal viromes, which are intertwined with the bacterial microbiome and host immune responses.

Although the mean amount of this reduction (about 2.5 PD) was clinically insignificant, 10 cases lost more than 10 PD of convergence amplitude which may be significant.

In developing organisms, growth hormone may play an important role in inducing insulin resistance under fasting stress conditions, which may be significant for the defense against hypoglycemia [ 146 ].