Barely Significant
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“may be significant”

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Mechanisms of injury at the cellular level remain unclear, but it may be significant that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19, uses angiotensin-converting expression enzyme 2 (ACE2), a key regulator of the ‘anti-inflammatory’ arm of the renin-angiotensin system, for viral attachment and host cell invasion.
Furthermore, these data indicate that the chemistry of the growth cone membrane is distinct from that of the neuron soma which may be significant for the mechanisms of guidance and recognition in the growing nerve tip. status released display-pdf yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Received 1974 Feb 4; Revised 1974 Apr 22.
The CD44 receptor on the surface of mastocytes is a receptor for HA and such an interaction may be significant in their migration. 32 , 55 Treatment involves the immediate administration of antihistamine drugs, systemic GCS, or adrenaline. 46 Early Reactions The first reports were published by Turkmani et al and described women aged 22–65 who had undergone procedures with HA manufactured by various companies. 39 Lesions presented as erythema and painful edema of the face at the sites of injected fillers.
The Immunogenicity of Hyaluronic Fillers and Its Consequences.
Clin Cosmet Investig Dermatol · 2021 · PMC8291382
Another important factor that may cause higher hardness of SIC/Ti 3 C 2 T X M composites and their higher fracture toughness in the range of 1–2 wt.% may be significant differences in the structure of carbon flakes and the quality of the matrix-carbon flake interface ( Figure 6 and Figure 7 ).