Barely Significant
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“may be significant”

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In the literature

This may be significant since injected substances in both placebo control arms have either a suggested association with autoimmune ovarian damage 17 or known direct ovarian toxicity. 47 Completed vaccine and placebo courses each administered 675 μg of aluminum to older girl safety study participants; or components including 150 μg polysorbate 80 to all 9- to 15-year-old safety study participants.
The example given by the social scientist refers to the “red” domain, where this or that technique may be significant for a more or less risky outcome; in the “green” biotech world, on the other hand, plants, animals and microorganisms are improved through methods that can be very traditional, like crossing sexually compatible (sometimes even incompatible) varieties and species, or more recently invented, like phy
Still, considering that heterozygous mutations show intermediate effects, and the possibility that common variant carriers have diminished TREM2 function by unknown mechanisms, it is reasonable to speculate that increased TREM2 activity above baseline may be beneficial, and that the approximately twofold increase in cell surface TREM2 that we observed with MEK inhibition may be significant.
Given this child-centred interactive focus, we can speculate that the first improvement is linked to the motivation and ability to meet other persons and interact through nonverbal cues, whereas progress in language may be significant to a lesser extent because they will emerge subsequently as the child becomes more willing to interact, communicate, make eye contact and share attention with others, which are prerequisites to develop verbal communication.